Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass membrane protein |
Domain |
PF04969 CS domain PF00443 Ubiquitin carboxyl-terminal hydrolase PF01753 MYND finger |
Function |
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. |
Biological Process |
GO:0001666 response to hypoxia GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0014706 striated muscle tissue development GO:0016202 regulation of striated muscle tissue development GO:0016579 protein deubiquitination GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0031647 regulation of protein stability GO:0034976 response to endoplasmic reticulum stress GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0036503 ERAD pathway GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045787 positive regulation of cell cycle GO:0045843 negative regulation of striated muscle tissue development GO:0045861 negative regulation of proteolysis GO:0048634 regulation of muscle organ development GO:0048635 negative regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048642 negative regulation of skeletal muscle tissue development GO:0050821 protein stabilization GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0061136 regulation of proteasomal protein catabolic process GO:0070482 response to oxygen levels GO:0070646 protein modification by small protein removal GO:0071108 protein K48-linked deubiquitination GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0090068 positive regulation of cell cycle process GO:1900037 regulation of cellular response to hypoxia GO:1901799 negative regulation of proteasomal protein catabolic process GO:1901861 regulation of muscle tissue development GO:1901862 negative regulation of muscle tissue development GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903363 negative regulation of cellular protein catabolic process GO:1904292 regulation of ERAD pathway |
Molecular Function |
GO:0004843 thiol-dependent ubiquitin-specific protease activity GO:0008234 cysteine-type peptidase activity GO:0019783 ubiquitin-like protein-specific protease activity GO:0031072 heat shock protein binding GO:0031625 ubiquitin protein ligase binding GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0044389 ubiquitin-like protein ligase binding GO:0051879 Hsp90 protein binding GO:0101005 ubiquitinyl hydrolase activity GO:1990380 Lys48-specific deubiquitinase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-5688426: Deubiquitination R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-5689880: Ub-specific processing proteases |
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between USP19 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of USP19 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of USP19 in various data sets.
|
Points in the above scatter plot represent the mutation difference of USP19 in various data sets.
|
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of USP19. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of USP19. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by USP19. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of USP19. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of USP19 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between USP19 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | USP19 |
Name | ubiquitin specific peptidase 19 |
Aliases | KIAA0891; ZMYND9; ubiquitin specific protease 19; deubiquitinating enzyme 19; ubiquitin thioesterase 19; ubi ...... |
Chromosomal Location | 3p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting USP19 collected from DrugBank database. |
There is no record. |