Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type II membrane protein |
Domain |
PF03567 Sulfotransferase family |
Function |
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin. |
Biological Process |
GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006029 proteoglycan metabolic process GO:0006477 protein sulfation GO:0006790 sulfur compound metabolic process GO:0007163 establishment or maintenance of cell polarity GO:0007409 axonogenesis GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0022604 regulation of cell morphogenesis GO:0030010 establishment of cell polarity GO:0030166 proteoglycan biosynthetic process GO:0030203 glycosaminoglycan metabolic process GO:0030205 dermatan sulfate metabolic process GO:0030208 dermatan sulfate biosynthetic process GO:0044272 sulfur compound biosynthetic process GO:0048667 cell morphogenesis involved in neuron differentiation GO:0050651 dermatan sulfate proteoglycan biosynthetic process GO:0050655 dermatan sulfate proteoglycan metabolic process GO:0050770 regulation of axonogenesis GO:0051923 sulfation GO:0061564 axon development GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0008146 sulfotransferase activity GO:0016782 transferase activity, transferring sulfur-containing groups |
Cellular Component | - |
KEGG |
hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
Reactome |
R-HSA-1793185: Chondroitin sulfate/dermatan sulfate metabolism R-HSA-2022923: Dermatan sulfate biosynthesis R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UST and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UST in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UST in various data sets.
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Points in the above scatter plot represent the mutation difference of UST in various data sets.
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Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UST. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UST. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UST. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UST. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UST expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UST |
Name | uronyl-2-sulfotransferase |
Aliases | dermatan/chondroitin sulfate 2-sulfotransferase; Uronyl 2-sulfotransferase |
Chromosomal Location | 6q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UST and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |