Browse UXS1

Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus, Golgi stack membrane Single-pass type II membrane protein
Domain PF16363 GDP-mannose 4
PF11803 UDP-glucuronate decarboxylase N-terminal
Function

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.

> Gene Ontology
 
Biological Process GO:0009225 nucleotide-sugar metabolic process
GO:0009226 nucleotide-sugar biosynthetic process
GO:0033319 UDP-D-xylose metabolic process
GO:0033320 UDP-D-xylose biosynthetic process
GO:0051259 protein oligomerization
GO:0051262 protein tetramerization
Molecular Function GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0048037 cofactor binding
GO:0048040 UDP-glucuronate decarboxylase activity
GO:0050662 coenzyme binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Cellular Component GO:0005795 Golgi stack
GO:0031984 organelle subcompartment
GO:0031985 Golgi cisterna
GO:0032580 Golgi cisterna membrane
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG hsa00520 Amino sugar and nucleotide sugar metabolism
hsa01100 Metabolic pathways
Reactome -
Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between UXS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of UXS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.54 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of UXS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2430.37
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.280.892
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2210.89
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0970.714
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3680.845
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2460.916
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0320.936
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2770.859
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2090.906
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1720.915
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.820.726
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0980.219
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of UXS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UXS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UXS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UXS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UXS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of UXS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between UXS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolUXS1
NameUDP-glucuronate decarboxylase 1
Aliases FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ......
Chromosomal Location2q12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting UXS1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.