Summary | |
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Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus, Golgi stack membrane Single-pass type II membrane protein |
Domain |
PF16363 GDP-mannose 4 PF11803 UDP-glucuronate decarboxylase N-terminal |
Function |
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. |
Biological Process |
GO:0009225 nucleotide-sugar metabolic process GO:0009226 nucleotide-sugar biosynthetic process GO:0033319 UDP-D-xylose metabolic process GO:0033320 UDP-D-xylose biosynthetic process GO:0051259 protein oligomerization GO:0051262 protein tetramerization |
Molecular Function |
GO:0016829 lyase activity GO:0016830 carbon-carbon lyase activity GO:0016831 carboxy-lyase activity GO:0048037 cofactor binding GO:0048040 UDP-glucuronate decarboxylase activity GO:0050662 coenzyme binding GO:0051287 NAD binding GO:0070403 NAD+ binding |
Cellular Component |
GO:0005795 Golgi stack GO:0031984 organelle subcompartment GO:0031985 Golgi cisterna GO:0032580 Golgi cisterna membrane GO:0098791 Golgi subcompartment |
KEGG |
hsa00520 Amino sugar and nucleotide sugar metabolism hsa01100 Metabolic pathways |
Reactome | - |
Summary | |
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Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between UXS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of UXS1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of UXS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of UXS1 in various data sets.
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Summary | |
---|---|
Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UXS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UXS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UXS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UXS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of UXS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between UXS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | UXS1 |
Name | UDP-glucuronate decarboxylase 1 |
Aliases | FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UXS-1; UDP-glucuronic acid decar ...... |
Chromosomal Location | 2q12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting UXS1 collected from DrugBank database. |
There is no record. |