Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane Note=Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651). |
Domain |
PF00957 Synaptobrevin |
Function |
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. |
Biological Process |
GO:0001505 regulation of neurotransmitter levels GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002278 eosinophil activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002447 eosinophil mediated immunity GO:0006813 potassium ion transport GO:0006820 anion transport GO:0006835 dicarboxylic acid transport GO:0006836 neurotransmitter transport GO:0006887 exocytosis GO:0006892 post-Golgi vesicle-mediated transport GO:0006906 vesicle fusion GO:0007009 plasma membrane organization GO:0007269 neurotransmitter secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0010959 regulation of metal ion transport GO:0014047 glutamate secretion GO:0015672 monovalent inorganic cation transport GO:0015711 organic anion transport GO:0016050 vesicle organization GO:0016079 synaptic vesicle exocytosis GO:0017156 calcium ion regulated exocytosis GO:0017157 regulation of exocytosis GO:0022898 regulation of transmembrane transporter activity GO:0023061 signal release GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032409 regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033157 regulation of intracellular protein transport GO:0034284 response to monosaccharide GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0036230 granulocyte activation GO:0043001 Golgi to plasma membrane protein transport GO:0043266 regulation of potassium ion transport GO:0043299 leukocyte degranulation GO:0043307 eosinophil activation GO:0043308 eosinophil degranulation GO:0043434 response to peptide hormone GO:0044801 single-organism membrane fusion GO:0045055 regulated exocytosis GO:0046942 carboxylic acid transport GO:0048167 regulation of synaptic plasticity GO:0048193 Golgi vesicle transport GO:0048284 organelle fusion GO:0048489 synaptic vesicle transport GO:0050804 modulation of synaptic transmission GO:0050806 positive regulation of synaptic transmission GO:0051222 positive regulation of protein transport GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0060291 long-term synaptic potentiation GO:0060627 regulation of vesicle-mediated transport GO:0061025 membrane fusion GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071804 cellular potassium ion transport GO:0071805 potassium ion transmembrane transport GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0090174 organelle membrane fusion GO:0090316 positive regulation of intracellular protein transport GO:0097479 synaptic vesicle localization GO:0097480 establishment of synaptic vesicle localization GO:0099003 vesicle-mediated transport in synapse GO:0099504 synaptic vesicle cycle GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099643 signal release from synapse GO:1901016 regulation of potassium ion transmembrane transporter activity GO:1901379 regulation of potassium ion transmembrane transport GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902259 regulation of delayed rectifier potassium channel activity GO:1903829 positive regulation of cellular protein localization GO:1904062 regulation of cation transmembrane transport GO:1904951 positive regulation of establishment of protein localization GO:1990778 protein localization to cell periphery GO:2001257 regulation of cation channel activity |
Molecular Function |
GO:0000149 SNARE binding GO:0005484 SNAP receptor activity GO:0005516 calmodulin binding GO:0005543 phospholipid binding GO:0017075 syntaxin-1 binding GO:0019905 syntaxin binding GO:0043621 protein self-association GO:0048306 calcium-dependent protein binding |
Cellular Component |
GO:0005802 trans-Golgi network GO:0008021 synaptic vesicle GO:0008076 voltage-gated potassium channel complex GO:0030133 transport vesicle GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030141 secretory granule GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030667 secretory granule membrane GO:0030672 synaptic vesicle membrane GO:0031201 SNARE complex GO:0031984 organelle subcompartment GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034705 potassium channel complex GO:0042588 zymogen granule GO:0042589 zymogen granule membrane GO:0044306 neuron projection terminus GO:0060198 clathrin-sculpted vesicle GO:0060199 clathrin-sculpted glutamate transport vesicle GO:0060203 clathrin-sculpted glutamate transport vesicle membrane GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070081 clathrin-sculpted monoamine transport vesicle GO:0070083 clathrin-sculpted monoamine transport vesicle membrane GO:0070382 exocytic vesicle GO:0098791 Golgi subcompartment GO:0098793 presynapse GO:0099501 exocytic vesicle membrane GO:0099503 secretory vesicle GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG |
hsa04130 SNARE interactions in vesicular transport hsa04721 Synaptic vesicle cycle hsa04911 Insulin secretion hsa04962 Vasopressin-regulated water reabsorption hsa04970 Salivary secretion |
Reactome |
R-HSA-264642: Acetylcholine Neurotransmitter Release Cycle R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-421837: Clathrin derived vesicle budding R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-1643685: Disease R-HSA-212676: Dopamine Neurotransmitter Release Cycle R-HSA-888590: GABA synthesis, release, reuptake and degradation R-HSA-210500: Glutamate Neurotransmitter Release Cycle R-HSA-432722: Golgi Associated Vesicle Biogenesis R-HSA-5663205: Infectious disease R-HSA-264876: Insulin processing R-HSA-163685: Integration of energy metabolism R-HSA-432720: Lysosome Vesicle Biogenesis R-HSA-199991: Membrane Trafficking R-HSA-1430728: Metabolism R-HSA-392499: Metabolism of proteins R-HSA-112316: Neuronal System R-HSA-168799: Neurotoxicity of clostridium toxins R-HSA-112310: Neurotransmitter Release Cycle R-HSA-181430: Norepinephrine Neurotransmitter Release Cycle R-HSA-2980736: Peptide hormone metabolism R-HSA-422356: Regulation of insulin secretion R-HSA-181429: Serotonin Neurotransmitter Release Cycle R-HSA-5250958: Toxicity of botulinum toxin type B (BoNT/B) R-HSA-5250955: Toxicity of botulinum toxin type D (BoNT/D) R-HSA-5250981: Toxicity of botulinum toxin type F (BoNT/F) R-HSA-5250989: Toxicity of botulinum toxin type G (BoNT/G) R-HSA-5250982: Toxicity of tetanus toxin (TeNT) R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-112315: Transmission across Chemical Synapses R-HSA-5339562: Uptake and actions of bacterial toxins R-HSA-5653656: Vesicle-mediated transport R-HSA-199992: trans-Golgi Network Vesicle Budding |
Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VAMP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of VAMP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VAMP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of VAMP2 in various data sets.
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Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VAMP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VAMP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VAMP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VAMP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VAMP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VAMP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | VAMP2 |
Name | vesicle-associated membrane protein 2 (synaptobrevin 2) |
Aliases | VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ...... |
Chromosomal Location | 17p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VAMP2 collected from DrugBank database. |
Details on drugs targeting VAMP2.
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