Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF06638 Strabismus protein |
Function |
- |
Biological Process |
GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0007164 establishment of tissue polarity GO:0016055 Wnt signaling pathway GO:0035567 non-canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0090175 regulation of establishment of planar polarity GO:0198738 cell-cell signaling by wnt GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis |
Molecular Function | - |
Cellular Component |
GO:0016328 lateral plasma membrane |
KEGG |
hsa04310 Wnt signaling pathway |
Reactome | - |
Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VANGL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between VANGL1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of VANGL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VANGL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of VANGL1 in various data sets.
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Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VANGL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VANGL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VANGL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VANGL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VANGL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VANGL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | VANGL1 |
Name | VANGL planar cell polarity protein 1 |
Aliases | STB2; vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila); vang-like 1 (van gogh, Drosoph ...... |
Chromosomal Location | 1p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VANGL1 collected from DrugBank database. |
There is no record. |