Summary | |
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Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type IV membrane protein Cell membrane Single-pass type IV membrane protein Cell junction, tight junction Nucleus membrane Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. |
Domain |
PF00635 MSP (Major sperm protein) domain |
Function |
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). |
Biological Process |
GO:0006643 membrane lipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006888 ER to Golgi vesicle-mediated transport GO:0006900 membrane budding GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0016050 vesicle organization GO:0019048 modulation by virus of host morphology or physiology GO:0019054 modulation by virus of host process GO:0019058 viral life cycle GO:0019076 viral release from host cell GO:0019079 viral genome replication GO:0030148 sphingolipid biosynthetic process GO:0035821 modification of morphology or physiology of other organism GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044003 modification by symbiont of host morphology or physiology GO:0044068 modulation by symbiont of host cellular process GO:0044788 modulation by host of viral process GO:0044789 modulation by host of viral release from host cell GO:0044791 positive regulation by host of viral release from host cell GO:0044793 negative regulation by host of viral process GO:0044794 positive regulation by host of viral process GO:0044827 modulation by host of viral genome replication GO:0044828 negative regulation by host of viral genome replication GO:0044829 positive regulation by host of viral genome replication GO:0045069 regulation of viral genome replication GO:0045070 positive regulation of viral genome replication GO:0045071 negative regulation of viral genome replication GO:0046467 membrane lipid biosynthetic process GO:0048193 Golgi vesicle transport GO:0048524 positive regulation of viral process GO:0048525 negative regulation of viral process GO:0050792 regulation of viral process GO:0051701 interaction with host GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0061025 membrane fusion GO:0070972 protein localization to endoplasmic reticulum GO:0090114 COPII-coated vesicle budding GO:1902186 regulation of viral release from host cell GO:1902188 positive regulation of viral release from host cell GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle GO:1903902 positive regulation of viral life cycle |
Molecular Function |
GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0033149 FFAT motif binding GO:0045296 cadherin binding GO:0046982 protein heterodimerization activity GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005635 nuclear envelope GO:0005913 cell-cell adherens junction GO:0005923 bicellular tight junction GO:0031965 nuclear membrane GO:0043296 apical junction complex GO:0070160 occluding junction |
KEGG | - |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-6798695: Neutrophil degranulation R-HSA-1660661: Sphingolipid de novo biosynthesis R-HSA-428157: Sphingolipid metabolism |
Summary | |
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Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VAPA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of VAPA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VAPA in various data sets.
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Points in the above scatter plot represent the mutation difference of VAPA in various data sets.
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Summary | |
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Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VAPA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VAPA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VAPA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VAPA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VAPA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VAPA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | VAPA |
Name | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa |
Aliases | hVAP-33; VAP-A; VAMP (vesicle-associated membrane protein)-associated protein A (33kD); VAP-33; VAP33; 33 kD ...... |
Chromosomal Location | 18p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VAPA collected from DrugBank database. |
There is no record. |