Summary | |
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Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. |
Domain |
PF00341 PDGF/VEGF domain PF14554 VEGF heparin-binding domain |
Function |
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). |
Biological Process |
GO:0001525 angiogenesis GO:0001541 ovarian follicle development GO:0001558 regulation of cell growth GO:0001569 patterning of blood vessels GO:0001570 vasculogenesis GO:0001654 eye development GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001754 eye photoreceptor cell differentiation GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001823 mesonephros development GO:0001894 tissue homeostasis GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0001945 lymph vessel development GO:0001952 regulation of cell-matrix adhesion GO:0001954 positive regulation of cell-matrix adhesion GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0002052 positive regulation of neuroblast proliferation GO:0002053 positive regulation of mesenchymal cell proliferation GO:0002090 regulation of receptor internalization GO:0002092 positive regulation of receptor internalization GO:0002262 myeloid cell homeostasis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002576 platelet degranulation GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0003169 coronary vein morphogenesis GO:0006140 regulation of nucleotide metabolic process GO:0006476 protein deacetylation GO:0006887 exocytosis GO:0006898 receptor-mediated endocytosis GO:0007044 cell-substrate junction assembly GO:0007045 cell-substrate adherens junction assembly GO:0007160 cell-matrix adhesion GO:0007389 pattern specification process GO:0007405 neuroblast proliferation GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007423 sensory organ development GO:0007498 mesoderm development GO:0007507 heart development GO:0007548 sex differentiation GO:0007589 body fluid secretion GO:0007595 lactation GO:0008360 regulation of cell shape GO:0008361 regulation of cell size GO:0008406 gonad development GO:0008585 female gonad development GO:0009150 purine ribonucleotide metabolic process GO:0009187 cyclic nucleotide metabolic process GO:0009791 post-embryonic development GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0010466 negative regulation of peptidase activity GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0010951 negative regulation of endopeptidase activity GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014706 striated muscle tissue development GO:0016049 cell growth GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018105 peptidyl-serine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018212 peptidyl-tyrosine modification GO:0021700 developmental maturation GO:0022602 ovulation cycle process GO:0022604 regulation of cell morphogenesis GO:0030099 myeloid cell differentiation GO:0030100 regulation of endocytosis GO:0030218 erythrocyte differentiation GO:0030224 monocyte differentiation GO:0030225 macrophage differentiation GO:0030307 positive regulation of cell growth GO:0030323 respiratory tube development GO:0030324 lung development GO:0030335 positive regulation of cell migration GO:0030516 regulation of axon extension GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030823 regulation of cGMP metabolic process GO:0030879 mammary gland development GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031063 regulation of histone deacetylation GO:0031065 positive regulation of histone deacetylation GO:0031077 post-embryonic camera-type eye development GO:0031098 stress-activated protein kinase signaling cascade GO:0031290 retinal ganglion cell axon guidance GO:0031334 positive regulation of protein complex assembly GO:0031346 positive regulation of cell projection organization GO:0031589 cell-substrate adhesion GO:0031623 receptor internalization GO:0031952 regulation of protein autophosphorylation GO:0031954 positive regulation of protein autophosphorylation GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032535 regulation of cellular component size GO:0032793 positive regulation of CREB transcription factor activity GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0032941 secretion by tissue GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033674 positive regulation of kinase activity GO:0034101 erythrocyte homeostasis GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0034333 adherens junction assembly GO:0035051 cardiocyte differentiation GO:0035148 tube formation GO:0035162 embryonic hemopoiesis GO:0035239 tube morphogenesis GO:0035601 protein deacylation GO:0035767 endothelial cell chemotaxis GO:0035886 vascular smooth muscle cell differentiation GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0036303 lymph vessel morphogenesis GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038066 p38MAPK cascade GO:0038083 peptidyl-tyrosine autophosphorylation GO:0038084 vascular endothelial growth factor signaling pathway GO:0038086 VEGF-activated platelet-derived growth factor receptor signaling pathway GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038189 neuropilin signaling pathway GO:0038190 VEGF-activated neuropilin signaling pathway GO:0040017 positive regulation of locomotion GO:0042461 photoreceptor cell development GO:0042462 eye photoreceptor cell development GO:0042692 muscle cell differentiation GO:0042698 ovulation cycle GO:0043010 camera-type eye development GO:0043112 receptor metabolic process GO:0043129 surfactant homeostasis GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043254 regulation of protein complex assembly GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0044089 positive regulation of cellular component biogenesis GO:0045055 regulated exocytosis GO:0045137 development of primary sexual characteristics GO:0045216 cell-cell junction organization GO:0045666 positive regulation of neuron differentiation GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045773 positive regulation of axon extension GO:0045785 positive regulation of cell adhesion GO:0045807 positive regulation of endocytosis GO:0045860 positive regulation of protein kinase activity GO:0045861 negative regulation of proteolysis GO:0045927 positive regulation of growth GO:0046068 cGMP metabolic process GO:0046530 photoreceptor cell differentiation GO:0046545 development of primary female sexual characteristics GO:0046660 female sex differentiation GO:0046777 protein autophosphorylation GO:0048008 platelet-derived growth factor receptor signaling pathway GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048041 focal adhesion assembly GO:0048259 regulation of receptor-mediated endocytosis GO:0048260 positive regulation of receptor-mediated endocytosis GO:0048469 cell maturation GO:0048511 rhythmic process GO:0048514 blood vessel morphogenesis GO:0048568 embryonic organ development GO:0048569 post-embryonic animal organ development GO:0048588 developmental cell growth GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048732 gland development GO:0048738 cardiac muscle tissue development GO:0048739 cardiac muscle fiber development GO:0048747 muscle fiber development GO:0048754 branching morphogenesis of an epithelial tube GO:0048841 regulation of axon extension involved in axon guidance GO:0048842 positive regulation of axon extension involved in axon guidance GO:0048844 artery morphogenesis GO:0048845 venous blood vessel morphogenesis GO:0048846 axon extension involved in axon guidance GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0048875 chemical homeostasis within a tissue GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050926 regulation of positive chemotaxis GO:0050927 positive regulation of positive chemotaxis GO:0050930 induction of positive chemotaxis GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051145 smooth muscle cell differentiation GO:0051146 striated muscle cell differentiation GO:0051272 positive regulation of cellular component movement GO:0051302 regulation of cell division GO:0051346 negative regulation of hydrolase activity GO:0051403 stress-activated MAPK cascade GO:0051781 positive regulation of cell division GO:0051893 regulation of focal adhesion assembly GO:0051894 positive regulation of focal adhesion assembly GO:0051962 positive regulation of nervous system development GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055006 cardiac cell development GO:0055007 cardiac muscle cell differentiation GO:0055013 cardiac muscle cell development GO:0060215 primitive hemopoiesis GO:0060249 anatomical structure homeostasis GO:0060319 primitive erythrocyte differentiation GO:0060326 cell chemotaxis GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060627 regulation of vesicle-mediated transport GO:0060675 ureteric bud morphogenesis GO:0060688 regulation of morphogenesis of a branching structure GO:0060749 mammary gland alveolus development GO:0060840 artery development GO:0060841 venous blood vessel development GO:0060947 cardiac vascular smooth muscle cell differentiation GO:0060948 cardiac vascular smooth muscle cell development GO:0060976 coronary vasculature development GO:0060977 coronary vasculature morphogenesis GO:0060982 coronary artery morphogenesis GO:0060993 kidney morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061213 positive regulation of mesonephros development GO:0061217 regulation of mesonephros development GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0061351 neural precursor cell proliferation GO:0061377 mammary gland lobule development GO:0061387 regulation of extent of cell growth GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061458 reproductive system development GO:0061564 axon development GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070482 response to oxygen levels GO:0070528 protein kinase C signaling GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071542 dopaminergic neuron differentiation GO:0071679 commissural neuron axon guidance GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0089700 protein kinase D signaling GO:0090036 regulation of protein kinase C signaling GO:0090037 positive regulation of protein kinase C signaling GO:0090045 positive regulation of deacetylase activity GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis GO:0090066 regulation of anatomical structure size GO:0090109 regulation of cell-substrate junction assembly GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090183 regulation of kidney development GO:0090184 positive regulation of kidney development GO:0090189 regulation of branching involved in ureteric bud morphogenesis GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis GO:0090259 regulation of retinal ganglion cell axon guidance GO:0090287 regulation of cellular response to growth factor stimulus GO:0090311 regulation of protein deacetylation GO:0090312 positive regulation of protein deacetylation GO:0090596 sensory organ morphogenesis GO:0097084 vascular smooth muscle cell development GO:0097485 neuron projection guidance GO:0098732 macromolecule deacylation GO:1900084 regulation of peptidyl-tyrosine autophosphorylation GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900542 regulation of purine nucleotide metabolic process GO:1900744 regulation of p38MAPK cascade GO:1900745 positive regulation of p38MAPK cascade GO:1901342 regulation of vasculature development GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901725 regulation of histone deacetylase activity GO:1901727 positive regulation of histone deacetylase activity GO:1901888 regulation of cell junction assembly GO:1901890 positive regulation of cell junction assembly GO:1902275 regulation of chromatin organization GO:1902284 neuron projection extension involved in neuron projection guidance GO:1902336 positive regulation of retinal ganglion cell axon guidance GO:1902667 regulation of axon guidance GO:1902669 positive regulation of axon guidance GO:1902692 regulation of neuroblast proliferation GO:1903131 mononuclear cell differentiation GO:1903391 regulation of adherens junction organization GO:1903393 positive regulation of adherens junction organization GO:1903570 regulation of protein kinase D signaling GO:1903572 positive regulation of protein kinase D signaling GO:1903670 regulation of sprouting angiogenesis GO:1903672 positive regulation of sprouting angiogenesis GO:1904018 positive regulation of vasculature development GO:1905269 positive regulation of chromatin organization GO:1905330 regulation of morphogenesis of an epithelium GO:1905332 positive regulation of morphogenesis of an epithelium GO:1990138 neuron projection extension GO:2000027 regulation of organ morphogenesis GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000147 positive regulation of cell motility GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000648 positive regulation of stem cell proliferation GO:2001026 regulation of endothelial cell chemotaxis GO:2001028 positive regulation of endothelial cell chemotaxis |
Molecular Function |
GO:0001968 fibronectin binding GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005161 platelet-derived growth factor receptor binding GO:0005172 vascular endothelial growth factor receptor binding GO:0005539 glycosaminoglycan binding GO:0008083 growth factor activity GO:0008201 heparin binding GO:0030545 receptor regulator activity GO:0030546 receptor activator activity GO:0042056 chemoattractant activity GO:0043183 vascular endothelial growth factor receptor 1 binding GO:0043184 vascular endothelial growth factor receptor 2 binding GO:0046982 protein heterodimerization activity GO:0048018 receptor agonist activity GO:0050840 extracellular matrix binding GO:0070851 growth factor receptor binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG |
hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04066 HIF-1 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04370 VEGF signaling pathway hsa04510 Focal adhesion |
Reactome |
R-HSA-422475: Axon guidance R-HSA-2262749: Cellular response to hypoxia R-HSA-2262752: Cellular responses to stress R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1266738: Developmental Biology R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928663: EPHA-mediated growth cone collapse R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-1234174: Regulation of Hypoxia-inducible Factor (HIF) by oxygen R-HSA-1234158: Regulation of gene expression by Hypoxia-inducible Factor R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-194138: Signaling by VEGF R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-195399: VEGF binds to VEGFR leading to receptor dimerization R-HSA-194313: VEGF ligand-receptor interactions R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VEGFA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between VEGFA and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of VEGFA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VEGFA in various data sets.
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Points in the above scatter plot represent the mutation difference of VEGFA in various data sets.
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Summary | |
---|---|
Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VEGFA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VEGFA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VEGFA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VEGFA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VEGFA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VEGFA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | VEGFA |
Name | vascular endothelial growth factor A |
Aliases | VEGF-A; VPF; VEGF; vascular endothelial growth factor; MVCD1; vascular permeability factor |
Chromosomal Location | 6p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VEGFA collected from DrugBank database. |
Details on drugs targeting VEGFA.
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