Summary | |
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Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Note=Colocalizes with vimentin-type intermediate filaments. |
Domain | - |
Function |
- |
Biological Process | - |
Molecular Function | - |
Cellular Component |
GO:0005882 intermediate filament GO:0045098 type III intermediate filament GO:0045111 intermediate filament cytoskeleton |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VMAC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of VMAC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VMAC in various data sets.
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Points in the above scatter plot represent the mutation difference of VMAC in various data sets.
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Summary | |
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Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VMAC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VMAC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VMAC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VMAC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VMAC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VMAC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | VMAC |
Name | vimentin-type intermediate filament associated coiled-coil protein |
Aliases | vimentin-type IF-associated coiled-coil protein; Vimentin-type intermediate filament-associated coiled-coil ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VMAC collected from DrugBank database. |
There is no record. |