Summary | |
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Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor |
Domain |
PF00795 Carbon-nitrogen hydrolase |
Function |
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. |
Biological Process |
GO:0002521 leukocyte differentiation GO:0002526 acute inflammatory response GO:0002544 chronic inflammatory response GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0006732 coenzyme metabolic process GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0006768 biotin metabolic process GO:0006979 response to oxidative stress GO:0007159 leukocyte cell-cell adhesion GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0015939 pantothenate metabolic process GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0033077 T cell differentiation in thymus GO:0033081 regulation of T cell differentiation in thymus GO:0033089 positive regulation of T cell differentiation in thymus GO:0034599 cellular response to oxidative stress GO:0036473 cell death in response to oxidative stress GO:0042110 T cell activation GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045785 positive regulation of cell adhesion GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051186 cofactor metabolic process GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation GO:0097193 intrinsic apoptotic signaling pathway GO:1900407 regulation of cellular response to oxidative stress GO:1900408 negative regulation of cellular response to oxidative stress GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1902882 regulation of response to oxidative stress GO:1902883 negative regulation of response to oxidative stress GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903201 regulation of oxidative stress-induced cell death GO:1903202 negative regulation of oxidative stress-induced cell death GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:2000398 regulation of thymocyte aggregation GO:2000400 positive regulation of thymocyte aggregation GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017159 pantetheine hydrolase activity |
Cellular Component |
GO:0031225 anchored component of membrane |
KEGG |
hsa00770 Pantothenate and CoA biosynthesis |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-1430728: Metabolism R-HSA-392499: Metabolism of proteins R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-196849: Metabolism of water-soluble vitamins and cofactors R-HSA-6798695: Neutrophil degranulation R-HSA-163125: Post-translational modification R-HSA-597592: Post-translational protein modification R-HSA-199220: Vitamin B5 (pantothenate) metabolism |
Summary | |
---|---|
Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VNN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of VNN1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VNN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of VNN1 in various data sets.
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Summary | |
---|---|
Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VNN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VNN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VNN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VNN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VNN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VNN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | VNN1 |
Name | vanin 1 |
Aliases | Tiff66; HDLCQ8; pantetheine hydrolase; vanin-1; vannin 1; vascular non-inflammatory molecule 1 |
Chromosomal Location | 6q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VNN1 collected from DrugBank database. |
There is no record. |