Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endosome Late endosome membrane Peripheral membrane protein Cytoplasmic side Lysosome membrane Peripheral membrane protein Cytoplasmic side Early endosome Cytoplasmic vesicle Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle, clathrin-coated vesicle |
Domain |
PF00637 Region in Clathrin and VPS PF12451 Vacuolar protein sorting protein 11 C terminal |
Function |
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). |
Biological Process |
GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0006887 exocytosis GO:0006904 vesicle docking involved in exocytosis GO:0006906 vesicle fusion GO:0006914 autophagy GO:0007032 endosome organization GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0007040 lysosome organization GO:0007041 lysosomal transport GO:0008333 endosome to lysosome transport GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016050 vesicle organization GO:0016197 endosomal transport GO:0016482 cytosolic transport GO:0022406 membrane docking GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031338 regulation of vesicle fusion GO:0031647 regulation of protein stability GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0034058 endosomal vesicle fusion GO:0035493 SNARE complex assembly GO:0035542 regulation of SNARE complex assembly GO:0042176 regulation of protein catabolic process GO:0043254 regulation of protein complex assembly GO:0044801 single-organism membrane fusion GO:0045022 early endosome to late endosome transport GO:0045732 positive regulation of protein catabolic process GO:0048278 vesicle docking GO:0048284 organelle fusion GO:0051222 positive regulation of protein transport GO:0060627 regulation of vesicle-mediated transport GO:0061025 membrane fusion GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0080171 lytic vacuole organization GO:0090174 organelle membrane fusion GO:0090316 positive regulation of intracellular protein transport GO:0098927 vesicle-mediated transport between endosomal compartments GO:1902115 regulation of organelle assembly GO:1903214 regulation of protein targeting to mitochondrion GO:1903335 regulation of vacuolar transport GO:1903337 positive regulation of vacuolar transport GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903533 regulation of protein targeting GO:1903649 regulation of cytoplasmic transport GO:1903651 positive regulation of cytoplasmic transport GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization GO:2000641 regulation of early endosome to late endosome transport GO:2000643 positive regulation of early endosome to late endosome transport |
Molecular Function |
GO:0000149 SNARE binding GO:0019905 syntaxin binding GO:0030674 protein binding, bridging GO:0060090 binding, bridging |
Cellular Component |
GO:0005765 lysosomal membrane GO:0005769 early endosome GO:0005770 late endosome GO:0005776 autophagosome GO:0010008 endosome membrane GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030897 HOPS complex GO:0031902 late endosome membrane GO:0044440 endosomal part GO:0098852 lytic vacuole membrane GO:0099023 tethring complex |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VPS11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of VPS11 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VPS11 in various data sets.
|
Points in the above scatter plot represent the mutation difference of VPS11 in various data sets.
|
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VPS11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VPS11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VPS11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VPS11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VPS11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VPS11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | VPS11 |
Name | vacuolar protein sorting 11 homolog (S. cerevisiae) |
Aliases | RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VPS11 collected from DrugBank database. |
There is no record. |