Browse VPS33A

Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasmic vesicle Late endosome membrane Peripheral membrane protein Cytoplasmic side Lysosome membrane Peripheral membrane protein Cytoplasmic side Early endosome Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle, clathrin-coated vesicle
Domain PF00995 Sec1 family
Function

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).

> Gene Ontology
 
Biological Process GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0006914 autophagy
GO:0007033 vacuole organization
GO:0007034 vacuolar transport
GO:0007041 lysosomal transport
GO:0008333 endosome to lysosome transport
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0022406 membrane docking
GO:0030099 myeloid cell differentiation
GO:0030220 platelet formation
GO:0032400 melanosome localization
GO:0032418 lysosome localization
GO:0033059 cellular pigmentation
GO:0036344 platelet morphogenesis
GO:0043473 pigmentation
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048278 vesicle docking
GO:0048284 organelle fusion
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051875 pigment granule localization
GO:0097352 autophagosome maturation
GO:0097576 vacuole fusion
Molecular Function -
Cellular Component GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0010008 endosome membrane
GO:0030117 membrane coat
GO:0030118 clathrin coat
GO:0030119 AP-type membrane coat adaptor complex
GO:0030123 AP-3 adaptor complex
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030897 HOPS complex
GO:0031902 late endosome membrane
GO:0044440 endosomal part
GO:0048475 coated membrane
GO:0071439 clathrin complex
GO:0098852 lytic vacuole membrane
GO:0099023 tethring complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between VPS33A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of VPS33A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.67; FDR: 0.00722 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of VPS33A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1580.393
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3330.836
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.030.98
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1420.569
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2370.881
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0240.991
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1180.699
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1370.922
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1030.947
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5040.635
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6380.701
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.120.0355
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of VPS33A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VPS33A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VPS33A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VPS33A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VPS33A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of VPS33A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between VPS33A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolVPS33A
Namevacuolar protein sorting 33 homolog A (S. cerevisiae)
Aliases vacuolar protein sorting 33A (yeast); hVPS33A; vacuolar protein sorting 33A; Vacuolar protein sorting-associ ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting VPS33A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.