Browse VPS37D

Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Late endosome membrane Peripheral membrane protein
Domain PF07200 Modifier of rudimentary (Mod(r)) protein
Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

> Gene Ontology
 
Biological Process GO:0006900 membrane budding
GO:0006914 autophagy
GO:0007032 endosome organization
GO:0007033 vacuole organization
GO:0007034 vacuolar transport
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0036257 multivesicular body organization
GO:0036258 multivesicular body assembly
GO:0039702 viral budding via host ESCRT complex
GO:0044766 multi-organism transport
GO:0044803 multi-organism membrane organization
GO:0046755 viral budding
GO:0046794 transport of virus
GO:0075733 intracellular transport of virus
GO:1902579 multi-organism localization
GO:1902581 multi-organism cellular localization
GO:1902583 multi-organism intracellular transport
GO:1902590 multi-organism organelle organization
GO:1902592 multi-organism membrane budding
Molecular Function -
Cellular Component GO:0000813 ESCRT I complex
GO:0005770 late endosome
GO:0010008 endosome membrane
GO:0031902 late endosome membrane
GO:0036452 ESCRT complex
GO:0044440 endosomal part
> KEGG and Reactome Pathway
 
KEGG hsa04144 Endocytosis
Reactome R-HSA-175474: Assembly Of The HIV Virion
R-HSA-162588: Budding and maturation of HIV virion
R-HSA-1643685: Disease
R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-199991: Membrane Trafficking
R-HSA-174490: Membrane binding and targetting of GAG proteins
R-HSA-174495: Synthesis And Processing Of GAG, GAGPOL Polyproteins
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between VPS37D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of VPS37D in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.65 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of VPS37D in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0550.901
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2490.804
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2790.736
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2610.701
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5520.61
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0950.944
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2650.53
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4460.488
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0280.968
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2840.77
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2170.871
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0590.774
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of VPS37D in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 1417011.8-11.80.488
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414014.3-14.31
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VPS37D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VPS37D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VPS37D.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VPS37D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of VPS37D expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between VPS37D and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolVPS37D
Namevacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location7q11.23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting VPS37D collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.