Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Late endosome membrane Peripheral membrane protein |
Domain |
PF07200 Modifier of rudimentary (Mod(r)) protein |
Function |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. |
Biological Process |
GO:0006900 membrane budding GO:0006914 autophagy GO:0007032 endosome organization GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0016050 vesicle organization GO:0016197 endosomal transport GO:0019058 viral life cycle GO:0019068 virion assembly GO:0036257 multivesicular body organization GO:0036258 multivesicular body assembly GO:0039702 viral budding via host ESCRT complex GO:0044766 multi-organism transport GO:0044803 multi-organism membrane organization GO:0046755 viral budding GO:0046794 transport of virus GO:0075733 intracellular transport of virus GO:1902579 multi-organism localization GO:1902581 multi-organism cellular localization GO:1902583 multi-organism intracellular transport GO:1902590 multi-organism organelle organization GO:1902592 multi-organism membrane budding |
Molecular Function | - |
Cellular Component |
GO:0000813 ESCRT I complex GO:0005770 late endosome GO:0010008 endosome membrane GO:0031902 late endosome membrane GO:0036452 ESCRT complex GO:0044440 endosomal part |
KEGG |
hsa04144 Endocytosis |
Reactome |
R-HSA-175474: Assembly Of The HIV Virion R-HSA-162588: Budding and maturation of HIV virion R-HSA-1643685: Disease R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-199991: Membrane Trafficking R-HSA-174490: Membrane binding and targetting of GAG proteins R-HSA-174495: Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VPS37D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of VPS37D in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VPS37D in various data sets.
|
Points in the above scatter plot represent the mutation difference of VPS37D in various data sets.
|
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VPS37D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VPS37D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VPS37D. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VPS37D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VPS37D expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VPS37D and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | VPS37D |
Name | vacuolar protein sorting 37 homolog D (S. cerevisiae) |
Aliases | MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VPS37D collected from DrugBank database. |
There is no record. |