Summary | |
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Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane Peripheral membrane protein Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells. |
Domain |
PF00004 ATPase family associated with various cellular activities (AAA) PF04212 MIT (microtubule interacting and transport) domain PF09336 Vps4 C terminal oligomerisation domain |
Function |
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000086 G2/M transition of mitotic cell cycle GO:0000226 microtubule cytoskeleton organization GO:0000819 sister chromatid segregation GO:0000920 cell separation after cytokinesis GO:0006813 potassium ion transport GO:0006869 lipid transport GO:0006887 exocytosis GO:0006900 membrane budding GO:0006914 autophagy GO:0006997 nucleus organization GO:0007032 endosome organization GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0007041 lysosomal transport GO:0007051 spindle organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007080 mitotic metaphase plate congression GO:0007088 regulation of mitotic nuclear division GO:0007098 centrosome cycle GO:0007099 centriole replication GO:0007346 regulation of mitotic cell cycle GO:0008333 endosome to lysosome transport GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0010824 regulation of centrosome duplication GO:0010825 positive regulation of centrosome duplication GO:0010876 lipid localization GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0015672 monovalent inorganic cation transport GO:0015850 organic hydroxy compound transport GO:0015918 sterol transport GO:0016050 vesicle organization GO:0016197 endosomal transport GO:0017157 regulation of exocytosis GO:0019058 viral life cycle GO:0019068 virion assembly GO:0019076 viral release from host cell GO:0030301 cholesterol transport GO:0031023 microtubule organizing center organization GO:0032509 endosome transport via multivesicular body sorting pathway GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway GO:0032886 regulation of microtubule-based process GO:0032984 macromolecular complex disassembly GO:0036257 multivesicular body organization GO:0036258 multivesicular body assembly GO:0039702 viral budding via host ESCRT complex GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043241 protein complex disassembly GO:0043624 cellular protein complex disassembly GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044089 positive regulation of cellular component biogenesis GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044803 multi-organism membrane organization GO:0044839 cell cycle G2/M phase transition GO:0045787 positive regulation of cell cycle GO:0045920 negative regulation of exocytosis GO:0045921 positive regulation of exocytosis GO:0045931 positive regulation of mitotic cell cycle GO:0046599 regulation of centriole replication GO:0046601 positive regulation of centriole replication GO:0046605 regulation of centrosome cycle GO:0046607 positive regulation of centrosome cycle GO:0046755 viral budding GO:0048524 positive regulation of viral process GO:0050000 chromosome localization GO:0050792 regulation of viral process GO:0051047 positive regulation of secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051225 spindle assembly GO:0051261 protein depolymerization GO:0051297 centrosome organization GO:0051298 centrosome duplication GO:0051303 establishment of chromosome localization GO:0051310 metaphase plate congression GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0051783 regulation of nuclear division GO:0060627 regulation of vesicle-mediated transport GO:0061511 centriole elongation GO:0061738 late endosomal microautophagy GO:0070507 regulation of microtubule cytoskeleton organization GO:0090068 positive regulation of cell cycle process GO:0090169 regulation of spindle assembly GO:0090224 regulation of spindle organization GO:0090307 mitotic spindle assembly GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway GO:0098534 centriole assembly GO:0098813 nuclear chromosome segregation GO:1901673 regulation of mitotic spindle assembly GO:1901987 regulation of cell cycle phase transition GO:1901989 positive regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901992 positive regulation of mitotic cell cycle phase transition GO:1902115 regulation of organelle assembly GO:1902117 positive regulation of organelle assembly GO:1902186 regulation of viral release from host cell GO:1902188 positive regulation of viral release from host cell GO:1902590 multi-organism organelle organization GO:1902592 multi-organism membrane budding GO:1902749 regulation of cell cycle G2/M phase transition GO:1902751 positive regulation of cell cycle G2/M phase transition GO:1902850 microtubule cytoskeleton organization involved in mitosis GO:1903531 negative regulation of secretion by cell GO:1903532 positive regulation of secretion by cell GO:1903541 regulation of exosomal secretion GO:1903542 negative regulation of exosomal secretion GO:1903543 positive regulation of exosomal secretion GO:1903722 regulation of centriole elongation GO:1903724 positive regulation of centriole elongation GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle GO:1904896 ESCRT complex disassembly GO:1904903 ESCRT III complex disassembly GO:1990182 exosomal secretion |
Molecular Function |
GO:0008022 protein C-terminus binding GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled |
Cellular Component |
GO:0000922 spindle pole GO:0005770 late endosome GO:0005813 centrosome GO:0005819 spindle GO:0010008 endosome membrane GO:0030496 midbody GO:0031902 late endosome membrane GO:0044440 endosomal part GO:0090543 Flemming body |
KEGG |
hsa04144 Endocytosis |
Reactome |
R-HSA-162588: Budding and maturation of HIV virion R-HSA-1643685: Disease R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between VPS4B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of VPS4B in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of VPS4B in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VPS4B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VPS4B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VPS4B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VPS4B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of VPS4B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between VPS4B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | VPS4B |
Name | vacuolar protein sorting 4 homolog B (S. cerevisiae) |
Aliases | VPS4-2; SKD1B; suppressor of K+ transport defect 1; vacuolar protein sorting 4B (yeast); MIG1; cell migratio ...... |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting VPS4B collected from DrugBank database. |
There is no record. |