Summary | |
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Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus speckle Nucleus Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes. |
Domain |
PF00397 WW domain |
Function |
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0006513 protein monoubiquitination GO:0006914 autophagy GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010390 histone monoubiquitination GO:0010498 proteasomal protein catabolic process GO:0010506 regulation of autophagy GO:0010508 positive regulation of autophagy GO:0016236 macroautophagy GO:0016239 positive regulation of macroautophagy GO:0016241 regulation of macroautophagy GO:0016570 histone modification GO:0016574 histone ubiquitination GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0031570 DNA integrity checkpoint GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0033523 histone H2B ubiquitination GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0044783 G1 DNA damage checkpoint GO:0045861 negative regulation of proteolysis GO:0061136 regulation of proteasomal protein catabolic process GO:0071894 histone H2B conserved C-terminal lysine ubiquitination GO:1901799 negative regulation of proteasomal protein catabolic process GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903363 negative regulation of cellular protein catabolic process |
Molecular Function |
GO:0000993 RNA polymerase II core binding GO:0001098 basal transcription machinery binding GO:0001099 basal RNA polymerase II transcription machinery binding GO:0003682 chromatin binding GO:0043175 RNA polymerase core enzyme binding GO:0070063 RNA polymerase binding |
Cellular Component |
GO:0005681 spliceosomal complex GO:0016604 nuclear body GO:0016607 nuclear speck |
KEGG | - |
Reactome |
R-HSA-8866654: E3 ubiquitin ligases ubiquitinate target proteins R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8852135: Protein ubiquitination |
Summary | |
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Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WAC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WAC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WAC in various data sets.
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Points in the above scatter plot represent the mutation difference of WAC in various data sets.
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Summary | |
---|---|
Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WAC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WAC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WAC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WAC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WAC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WAC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | WAC |
Name | WW domain containing adaptor with coiled-coil |
Aliases | FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ...... |
Chromosomal Location | 10p12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting WAC collected from DrugBank database. |
There is no record. |