Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Nucleus, nucleoplasm Cytoplasm, perinuclear region Cytoplasm Note=Localized diffusely throughout the nucleus and the cytoplasm (PubMed:24488492). Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604). Localization is not affected by glucocorticoid treatment (PubMed:24488492). |
Domain |
PF08241 Methyltransferase domain PF12589 Methyltransferase involved in Williams-Beuren syndrome |
Function |
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). |
Biological Process |
GO:0000154 rRNA modification GO:0001510 RNA methylation GO:0006364 rRNA processing GO:0009451 RNA modification GO:0016072 rRNA metabolic process GO:0022613 ribonucleoprotein complex biogenesis GO:0031167 rRNA methylation GO:0032259 methylation GO:0034470 ncRNA processing GO:0042254 ribosome biogenesis GO:0043414 macromolecule methylation |
Molecular Function |
GO:0008168 methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6790901: rRNA modification in the nucleus and cytosol R-HSA-72312: rRNA processing R-HSA-8868773: rRNA processing in the nucleus and cytosol |
Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WBSCR22 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WBSCR22 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WBSCR22 in various data sets.
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Points in the above scatter plot represent the mutation difference of WBSCR22 in various data sets.
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Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WBSCR22. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WBSCR22. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WBSCR22. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WBSCR22. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WBSCR22 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WBSCR22 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | WBSCR22 |
Name | Williams Beuren syndrome chromosome region 22 |
Aliases | MGC19709; MGC2022; MGC5140; PP3381; WBMT; MERM1; metastasis-related methyltransferase 1; HASJ4442; HUSSY-3; ...... |
Chromosomal Location | 7q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting WBSCR22 collected from DrugBank database. |
There is no record. |