Summary | |
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Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Lysosome membrane |
Domain |
PF00400 WD domain |
Function |
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). |
Biological Process |
GO:0006914 autophagy GO:0009267 cellular response to starvation GO:0009991 response to extracellular stimulus GO:0010506 regulation of autophagy GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031929 TOR signaling GO:0032006 regulation of TOR signaling GO:0032008 positive regulation of TOR signaling GO:0034198 cellular response to amino acid starvation GO:0042594 response to starvation GO:0071496 cellular response to external stimulus |
Molecular Function | - |
Cellular Component |
GO:0035859 Seh1-associated complex GO:0061700 GATOR2 complex |
KEGG |
hsa04150 mTOR signaling pathway |
Reactome | - |
Summary | |
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Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WDR24 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WDR24 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WDR24 in various data sets.
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Points in the above scatter plot represent the mutation difference of WDR24 in various data sets.
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Summary | |
---|---|
Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WDR24. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WDR24. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WDR24. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WDR24. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WDR24 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WDR24 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | WDR24 |
Name | WD repeat domain 24 |
Aliases | DKFZp434F054; JFP7; C16orf21; chromosome 16 open reading frame 21; WD repeat-containing protein 24 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting WDR24 collected from DrugBank database. |
There is no record. |