Summary | |
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Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00400 WD domain |
Function |
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. |
Biological Process |
GO:0001510 RNA methylation GO:0006399 tRNA metabolic process GO:0006400 tRNA modification GO:0008033 tRNA processing GO:0009451 RNA modification GO:0009452 7-methylguanosine RNA capping GO:0030488 tRNA methylation GO:0032259 methylation GO:0034470 ncRNA processing GO:0036260 RNA capping GO:0036265 RNA (guanine-N7)-methylation GO:0043414 macromolecule methylation |
Molecular Function |
GO:0008168 methyltransferase activity GO:0008173 RNA methyltransferase activity GO:0008175 tRNA methyltransferase activity GO:0008176 tRNA (guanine-N7-)-methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016423 tRNA (guanine) methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups |
Cellular Component |
GO:0034708 methyltransferase complex GO:0043527 tRNA methyltransferase complex |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6782315: tRNA modification in the nucleus and cytosol R-HSA-72306: tRNA processing |
Summary | |
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Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WDR4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between WDR4 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WDR4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WDR4 in various data sets.
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Points in the above scatter plot represent the mutation difference of WDR4 in various data sets.
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Summary | |
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Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WDR4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WDR4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WDR4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WDR4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WDR4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WDR4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | WDR4 |
Name | WD repeat domain 4 |
Aliases | TRM82; TRMT82; TRM82 tRNA methyltransferase 82 homolog (S. cerevisiae); TRM82 tRNA methyltransferase 82 homo ...... |
Chromosomal Location | 21q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting WDR4 collected from DrugBank database. |
There is no record. |