Summary | |
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Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic vesicle |
Domain |
PF00400 WD domain |
Function |
Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. |
Biological Process |
GO:0031214 biomineral tissue development GO:0034505 tooth mineralization GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0070166 enamel mineralization GO:0097186 amelogenesis |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WDR72 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WDR72 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WDR72 in various data sets.
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Points in the above scatter plot represent the mutation difference of WDR72 in various data sets.
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Summary | |
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Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WDR72. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WDR72. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WDR72. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WDR72. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WDR72 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | WDR72 |
Name | WD repeat domain 72 |
Aliases | FLJ38736; AI2A3; WD repeat-containing protein 72 |
Chromosomal Location | 15q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WDR72 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |