Summary | |
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Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00007 Cystine-knot domain PF00219 Insulin-like growth factor binding protein PF00090 Thrombospondin type 1 domain PF00093 von Willebrand factor type C domain |
Function |
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. |
Biological Process |
GO:0001558 regulation of cell growth GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0198738 cell-cell signaling by wnt |
Molecular Function |
GO:0005178 integrin binding GO:0005520 insulin-like growth factor binding GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0019838 growth factor binding GO:0050839 cell adhesion molecule binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WISP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WISP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WISP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of WISP1 in various data sets.
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Summary | |
---|---|
Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WISP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WISP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WISP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WISP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WISP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WISP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | WISP1 |
Name | WNT1 inducible signaling pathway protein 1 |
Aliases | CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ...... |
Chromosomal Location | 8q24.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting WISP1 collected from DrugBank database. |
There is no record. |