Browse WISP1

Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00007 Cystine-knot domain
PF00219 Insulin-like growth factor binding protein
PF00090 Thrombospondin type 1 domain
PF00093 von Willebrand factor type C domain
Function

Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0016049 cell growth
GO:0016055 Wnt signaling pathway
GO:0198738 cell-cell signaling by wnt
Molecular Function GO:0005178 integrin binding
GO:0005520 insulin-like growth factor binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0019838 growth factor binding
GO:0050839 cell adhesion molecule binding
GO:1901681 sulfur compound binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between WISP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of WISP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of WISP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.3340.00249
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.3390.182
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.3210.0667
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3230.682
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8810.592
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3910.861
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0350.943
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3810.737
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3340.79
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.8470.0854
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 283.4780.0117
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4640.0527
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of WISP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59400400.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WISP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WISP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WISP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WISP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of WISP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between WISP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolWISP1
NameWNT1 inducible signaling pathway protein 1
Aliases CCN4; CCN4c; WISP1i; WISP1tc; CCN family member 4; CTC-458A3.8; WNT1 induced secreted protein 1; Wnt-1 induc ......
Chromosomal Location8q24.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting WISP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.