Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix Secreted |
Domain |
PF00110 wnt family |
Function |
Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. |
Biological Process |
GO:0000086 G2/M transition of mitotic cell cycle GO:0001101 response to acid chemical GO:0001501 skeletal system development GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001942 hair follicle development GO:0002062 chondrocyte differentiation GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0007050 cell cycle arrest GO:0007224 smoothened signaling pathway GO:0007346 regulation of mitotic cell cycle GO:0007423 sensory organ development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0008544 epidermis development GO:0009415 response to water GO:0009894 regulation of catabolic process GO:0010035 response to inorganic substance GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0010498 proteasomal protein catabolic process GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0014074 response to purine-containing compound GO:0014706 striated muscle tissue development GO:0014835 myoblast differentiation involved in skeletal muscle regeneration GO:0014902 myotube differentiation GO:0014904 myotube cell development GO:0016055 Wnt signaling pathway GO:0016202 regulation of striated muscle tissue development GO:0021700 developmental maturation GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030278 regulation of ossification GO:0030282 bone mineralization GO:0030500 regulation of bone mineralization GO:0030501 positive regulation of bone mineralization GO:0030856 regulation of epithelial cell differentiation GO:0030858 positive regulation of epithelial cell differentiation GO:0031099 regeneration GO:0031214 biomineral tissue development GO:0031329 regulation of cellular catabolic process GO:0031334 positive regulation of protein complex assembly GO:0031647 regulation of protein stability GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032526 response to retinoic acid GO:0042176 regulation of protein catabolic process GO:0042246 tissue regeneration GO:0042303 molting cycle GO:0042633 hair cycle GO:0042634 regulation of hair cycle GO:0042635 positive regulation of hair cycle GO:0042640 anagen GO:0042692 muscle cell differentiation GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043254 regulation of protein complex assembly GO:0043403 skeletal muscle tissue regeneration GO:0043586 tongue development GO:0043588 skin development GO:0044089 positive regulation of cellular component biogenesis GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0044848 biological phase GO:0044851 hair cycle phase GO:0045165 cell fate commitment GO:0045444 fat cell differentiation GO:0045445 myoblast differentiation GO:0045598 regulation of fat cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045682 regulation of epidermis development GO:0045684 positive regulation of epidermis development GO:0045778 positive regulation of ossification GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045931 positive regulation of mitotic cell cycle GO:0046683 response to organophosphorus GO:0048634 regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048705 skeletal system morphogenesis GO:0048741 skeletal muscle fiber development GO:0048747 muscle fiber development GO:0048818 positive regulation of hair follicle maturation GO:0048819 regulation of hair follicle maturation GO:0048820 hair follicle maturation GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050821 protein stabilization GO:0050909 sensory perception of taste GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:0051146 striated muscle cell differentiation GO:0051216 cartilage development GO:0051591 response to cAMP GO:0051599 response to hydrostatic pressure GO:0051797 regulation of hair follicle development GO:0051798 positive regulation of hair follicle development GO:0051884 regulation of anagen GO:0051885 positive regulation of anagen GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0060070 canonical Wnt signaling pathway GO:0060260 regulation of transcription initiation from RNA polymerase II promoter GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter GO:0060343 trabecula formation GO:0060346 bone trabecula formation GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060828 regulation of canonical Wnt signaling pathway GO:0061136 regulation of proteasomal protein catabolic process GO:0061196 fungiform papilla development GO:0061383 trabecula morphogenesis GO:0061430 bone trabecula morphogenesis GO:0061448 connective tissue development GO:0065004 protein-DNA complex assembly GO:0070167 regulation of biomineral tissue development GO:0070169 positive regulation of biomineral tissue development GO:0070897 DNA-templated transcriptional preinitiation complex assembly GO:0071107 response to parathyroid hormone GO:0071214 cellular response to abiotic stimulus GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071320 cellular response to cAMP GO:0071374 cellular response to parathyroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071425 hematopoietic stem cell proliferation GO:0071462 cellular response to water stimulus GO:0071464 cellular response to hydrostatic pressure GO:0071695 anatomical structure maturation GO:0071824 protein-DNA complex subunit organization GO:0072089 stem cell proliferation GO:0090068 positive regulation of cell cycle process GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0098773 skin epidermis development GO:0198738 cell-cell signaling by wnt GO:1901861 regulation of muscle tissue development GO:1901987 regulation of cell cycle phase transition GO:1901989 positive regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901992 positive regulation of mitotic cell cycle phase transition GO:1902749 regulation of cell cycle G2/M phase transition GO:1902751 positive regulation of cell cycle G2/M phase transition GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:2000142 regulation of DNA-templated transcription, initiation GO:2000144 positive regulation of DNA-templated transcription, initiation |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005109 frizzled binding GO:0030545 receptor regulator activity GO:0030546 receptor activator activity GO:0048018 receptor agonist activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG |
hsa04150 mTOR signaling pathway hsa04310 Wnt signaling pathway hsa04390 Hippo signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04916 Melanogenesis |
Reactome |
R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-1266738: Developmental Biology R-HSA-500792: GPCR ligand binding R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-195721: Signaling by Wnt R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-3238698: WNT ligand biogenesis and trafficking |
Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WNT10B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WNT10B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WNT10B in various data sets.
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Points in the above scatter plot represent the mutation difference of WNT10B in various data sets.
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Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WNT10B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WNT10B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WNT10B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WNT10B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WNT10B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WNT10B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | WNT10B |
Name | wingless-type MMTV integration site family, member 10B |
Aliases | WNT-12; SHFM6; WNT-10B protein; Protein Wnt-12; Protein Wnt-10b |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting WNT10B collected from DrugBank database. |
There is no record. |