Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix Secreted |
Domain |
PF00110 wnt family |
Function |
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). |
Biological Process |
GO:0001101 response to acid chemical GO:0001654 eye development GO:0001701 in utero embryonic development GO:0001759 organ induction GO:0001763 morphogenesis of a branching structure GO:0001837 epithelial to mesenchymal transition GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0002053 positive regulation of mesenchymal cell proliferation GO:0002088 lens development in camera-type eye GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003156 regulation of animal organ formation GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003209 cardiac atrium morphogenesis GO:0003228 atrial cardiac muscle tissue development GO:0003230 cardiac atrium development GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007507 heart development GO:0007517 muscle organ development GO:0009952 anterior/posterior pattern specification GO:0010092 specification of animal organ identity GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0010720 positive regulation of cell development GO:0014706 striated muscle tissue development GO:0014855 striated muscle cell proliferation GO:0016055 Wnt signaling pathway GO:0016202 regulation of striated muscle tissue development GO:0016331 morphogenesis of embryonic epithelium GO:0021953 central nervous system neuron differentiation GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030323 respiratory tube development GO:0030324 lung development GO:0030879 mammary gland development GO:0030901 midbrain development GO:0031128 developmental induction GO:0032526 response to retinoic acid GO:0033002 muscle cell proliferation GO:0033278 cell proliferation in midbrain GO:0035239 tube morphogenesis GO:0035265 organ growth GO:0040019 positive regulation of embryonic development GO:0043010 camera-type eye development GO:0045165 cell fate commitment GO:0045844 positive regulation of striated muscle tissue development GO:0045927 positive regulation of growth GO:0045995 regulation of embryonic development GO:0046620 regulation of organ growth GO:0046622 positive regulation of organ growth GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048608 reproductive structure development GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048644 muscle organ morphogenesis GO:0048645 animal organ formation GO:0048732 gland development GO:0048738 cardiac muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050769 positive regulation of neurogenesis GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051962 positive regulation of nervous system development GO:0055008 cardiac muscle tissue morphogenesis GO:0055009 atrial cardiac muscle tissue morphogenesis GO:0055017 cardiac muscle tissue growth GO:0055021 regulation of cardiac muscle tissue growth GO:0055023 positive regulation of cardiac muscle tissue growth GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0060038 cardiac muscle cell proliferation GO:0060043 regulation of cardiac muscle cell proliferation GO:0060045 positive regulation of cardiac muscle cell proliferation GO:0060070 canonical Wnt signaling pathway GO:0060317 cardiac epithelial to mesenchymal transition GO:0060415 muscle tissue morphogenesis GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060421 positive regulation of heart growth GO:0060423 foregut regionalization GO:0060424 lung field specification GO:0060425 lung morphogenesis GO:0060428 lung epithelium development GO:0060431 primary lung bud formation GO:0060441 epithelial tube branching involved in lung morphogenesis GO:0060485 mesenchyme development GO:0060492 lung induction GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060502 epithelial cell proliferation involved in lung morphogenesis GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060562 epithelial tube morphogenesis GO:0060571 morphogenesis of an epithelial fold GO:0060572 morphogenesis of an epithelial bud GO:0060674 placenta blood vessel development GO:0060688 regulation of morphogenesis of a branching structure GO:0060711 labyrinthine layer development GO:0060716 labyrinthine layer blood vessel development GO:0060828 regulation of canonical Wnt signaling pathway GO:0061046 regulation of branching involved in lung morphogenesis GO:0061047 positive regulation of branching involved in lung morphogenesis GO:0061072 iris morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061180 mammary gland epithelium development GO:0061351 neural precursor cell proliferation GO:0061458 reproductive system development GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:0071542 dopaminergic neuron differentiation GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0090596 sensory organ morphogenesis GO:0198738 cell-cell signaling by wnt GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1904948 midbrain dopaminergic neuron differentiation GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1905330 regulation of morphogenesis of an epithelium GO:1905332 positive regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005109 frizzled binding GO:0005125 cytokine activity GO:0030545 receptor regulator activity GO:0030546 receptor activator activity GO:0048018 receptor agonist activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:1990909 Wnt signalosome |
KEGG |
hsa04150 mTOR signaling pathway hsa04310 Wnt signaling pathway hsa04390 Hippo signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04916 Melanogenesis |
Reactome |
R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-500792: GPCR ligand binding R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-195721: Signaling by Wnt R-HSA-3238698: WNT ligand biogenesis and trafficking |
Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WNT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between WNT2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WNT2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WNT2 in various data sets.
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Points in the above scatter plot represent the mutation difference of WNT2 in various data sets.
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Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WNT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WNT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WNT2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WNT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WNT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WNT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | WNT2 |
Name | wingless-type MMTV integration site family member 2 |
Aliases | IRP; secreted growth factor; INT1L1; Int-1-related protein; int-1-like protein 1; Protein Wnt-2 |
Chromosomal Location | 7q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting WNT2 collected from DrugBank database. |
There is no record. |