Summary | |
---|---|
Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix Secreted |
Domain |
PF00110 wnt family |
Function |
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). |
Biological Process |
GO:0000187 activation of MAPK activity GO:0000578 embryonic axis specification GO:0001101 response to acid chemical GO:0001501 skeletal system development GO:0001503 ossification GO:0001525 angiogenesis GO:0001558 regulation of cell growth GO:0001654 eye development GO:0001655 urogenital system development GO:0001667 ameboidal-type cell migration GO:0001702 gastrulation with mouth forming second GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001756 somitogenesis GO:0001763 morphogenesis of a branching structure GO:0001819 positive regulation of cytokine production GO:0001837 epithelial to mesenchymal transition GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0001947 heart looping GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002011 morphogenesis of an epithelial sheet GO:0002053 positive regulation of mesenchymal cell proliferation GO:0002064 epithelial cell development GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002066 columnar/cuboidal epithelial cell development GO:0002067 glandular epithelial cell differentiation GO:0002068 glandular epithelial cell development GO:0002072 optic cup morphogenesis involved in camera-type eye development GO:0002088 lens development in camera-type eye GO:0002237 response to molecule of bacterial origin GO:0002274 myeloid leukocyte activation GO:0002367 cytokine production involved in immune response GO:0002374 cytokine secretion involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002739 regulation of cytokine secretion involved in immune response GO:0002741 positive regulation of cytokine secretion involved in immune response GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003143 embryonic heart tube morphogenesis GO:0003151 outflow tract morphogenesis GO:0003156 regulation of animal organ formation GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003209 cardiac atrium morphogenesis GO:0003213 cardiac right atrium morphogenesis GO:0003230 cardiac atrium development GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0003306 Wnt signaling pathway involved in heart development GO:0003309 type B pancreatic cell differentiation GO:0003323 type B pancreatic cell development GO:0003344 pericardium morphogenesis GO:0003401 axis elongation GO:0003402 planar cell polarity pathway involved in axis elongation GO:0003408 optic cup formation involved in camera-type eye development GO:0006140 regulation of nucleotide metabolic process GO:0006582 melanin metabolic process GO:0007126 meiotic nuclear division GO:0007163 establishment or maintenance of cell polarity GO:0007164 establishment of tissue polarity GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007223 Wnt signaling pathway, calcium modulating pathway GO:0007254 JNK cascade GO:0007257 activation of JUN kinase activity GO:0007350 blastoderm segmentation GO:0007351 tripartite regional subdivision GO:0007368 determination of left/right symmetry GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007416 synapse assembly GO:0007423 sensory organ development GO:0007442 hindgut morphogenesis GO:0007494 midgut development GO:0007498 mesoderm development GO:0007507 heart development GO:0007517 muscle organ development GO:0007548 sex differentiation GO:0008361 regulation of cell size GO:0008406 gonad development GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008544 epidermis development GO:0008584 male gonad development GO:0008595 anterior/posterior axis specification, embryo GO:0009150 purine ribonucleotide metabolic process GO:0009187 cyclic nucleotide metabolic process GO:0009306 protein secretion GO:0009798 axis specification GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0009880 embryonic pattern specification GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009913 epidermal cell differentiation GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0010818 T cell chemotaxis GO:0010819 regulation of T cell chemotaxis GO:0010820 positive regulation of T cell chemotaxis GO:0010934 macrophage cytokine production GO:0010935 regulation of macrophage cytokine production GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014020 primary neural tube formation GO:0014706 striated muscle tissue development GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0018958 phenol-containing compound metabolic process GO:0019748 secondary metabolic process GO:0021536 diencephalon development GO:0021537 telencephalon development GO:0021772 olfactory bulb development GO:0021872 forebrain generation of neurons GO:0021879 forebrain neuron differentiation GO:0021884 forebrain neuron development GO:0021889 olfactory bulb interneuron differentiation GO:0021891 olfactory bulb interneuron development GO:0021915 neural tube development GO:0021953 central nervous system neuron differentiation GO:0021954 central nervous system neuron development GO:0021983 pituitary gland development GO:0021988 olfactory lobe development GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022604 regulation of cell morphogenesis GO:0022612 gland morphogenesis GO:0030010 establishment of cell polarity GO:0030100 regulation of endocytosis GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030216 keratinocyte differentiation GO:0030278 regulation of ossification GO:0030308 negative regulation of cell growth GO:0030323 respiratory tube development GO:0030324 lung development GO:0030326 embryonic limb morphogenesis GO:0030335 positive regulation of cell migration GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030514 negative regulation of BMP signaling pathway GO:0030516 regulation of axon extension GO:0030517 negative regulation of axon extension GO:0030540 female genitalia development GO:0030595 leukocyte chemotaxis GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030823 regulation of cGMP metabolic process GO:0030825 positive regulation of cGMP metabolic process GO:0030850 prostate gland development GO:0030859 polarized epithelial cell differentiation GO:0030879 mammary gland development GO:0030900 forebrain development GO:0030901 midbrain development GO:0030903 notochord development GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0031076 embryonic camera-type eye development GO:0031098 stress-activated protein kinase signaling cascade GO:0031345 negative regulation of cell projection organization GO:0031346 positive regulation of cell projection organization GO:0031349 positive regulation of defense response GO:0032092 positive regulation of protein binding GO:0032102 negative regulation of response to external stimulus GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032148 activation of protein kinase B activity GO:0032496 response to lipopolysaccharide GO:0032526 response to retinoic acid GO:0032535 regulation of cellular component size GO:0032602 chemokine production GO:0032609 interferon-gamma production GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032635 interleukin-6 production GO:0032637 interleukin-8 production GO:0032642 regulation of chemokine production GO:0032649 regulation of interferon-gamma production GO:0032651 regulation of interleukin-1 beta production GO:0032652 regulation of interleukin-1 production GO:0032675 regulation of interleukin-6 production GO:0032677 regulation of interleukin-8 production GO:0032722 positive regulation of chemokine production GO:0032729 positive regulation of interferon-gamma production GO:0032731 positive regulation of interleukin-1 beta production GO:0032732 positive regulation of interleukin-1 production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033278 cell proliferation in midbrain GO:0033598 mammary gland epithelial cell proliferation GO:0033674 positive regulation of kinase activity GO:0034340 response to type I interferon GO:0034341 response to interferon-gamma GO:0035050 embryonic heart tube development GO:0035088 establishment or maintenance of apical/basal cell polarity GO:0035089 establishment of apical/basal cell polarity GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035270 endocrine system development GO:0035282 segmentation GO:0035418 protein localization to synapse GO:0035567 non-canonical Wnt signaling pathway GO:0035883 enteroendocrine cell differentiation GO:0036342 post-anal tail morphogenesis GO:0036514 dopaminergic neuron axon guidance GO:0036515 serotonergic neuron axon guidance GO:0036517 chemoattraction of serotonergic neuron axon GO:0036518 chemorepulsion of dopaminergic neuron axon GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade GO:0038031 non-canonical Wnt signaling pathway via JNK cascade GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0040020 regulation of meiotic nuclear division GO:0040036 regulation of fibroblast growth factor receptor signaling pathway GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway GO:0042033 chemokine biosynthetic process GO:0042035 regulation of cytokine biosynthetic process GO:0042074 cell migration involved in gastrulation GO:0042089 cytokine biosynthetic process GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042116 macrophage activation GO:0042176 regulation of protein catabolic process GO:0042249 establishment of planar polarity of embryonic epithelium GO:0042438 melanin biosynthetic process GO:0042440 pigment metabolic process GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042695 thelarche GO:0042733 embryonic digit morphogenesis GO:0043010 camera-type eye development GO:0043030 regulation of macrophage activation GO:0043032 positive regulation of macrophage activation GO:0043393 regulation of protein binding GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043455 regulation of secondary metabolic process GO:0043506 regulation of JUN kinase activity GO:0043507 positive regulation of JUN kinase activity GO:0043542 endothelial cell migration GO:0043583 ear development GO:0043588 skin development GO:0044331 cell-cell adhesion mediated by cadherin GO:0044344 cellular response to fibroblast growth factor stimulus GO:0044550 secondary metabolite biosynthetic process GO:0045073 regulation of chemokine biosynthetic process GO:0045080 positive regulation of chemokine biosynthetic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045136 development of secondary sexual characteristics GO:0045137 development of primary sexual characteristics GO:0045165 cell fate commitment GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity GO:0045198 establishment of epithelial cell apical/basal polarity GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0045665 negative regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation GO:0045732 positive regulation of protein catabolic process GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045778 positive regulation of ossification GO:0045785 positive regulation of cell adhesion GO:0045787 positive regulation of cell cycle GO:0045807 positive regulation of endocytosis GO:0045836 positive regulation of meiotic nuclear division GO:0045860 positive regulation of protein kinase activity GO:0045926 negative regulation of growth GO:0045981 positive regulation of nucleotide metabolic process GO:0045992 negative regulation of embryonic development GO:0045995 regulation of embryonic development GO:0046068 cGMP metabolic process GO:0046148 pigment biosynthetic process GO:0046189 phenol-containing compound biosynthetic process GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046543 development of secondary female sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046660 female sex differentiation GO:0046661 male sex differentiation GO:0048021 regulation of melanin biosynthetic process GO:0048022 negative regulation of melanin biosynthetic process GO:0048048 embryonic eye morphogenesis GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048247 lymphocyte chemotaxis GO:0048332 mesoderm morphogenesis GO:0048339 paraxial mesoderm development GO:0048340 paraxial mesoderm morphogenesis GO:0048341 paraxial mesoderm formation GO:0048514 blood vessel morphogenesis GO:0048546 digestive tract morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048570 notochord morphogenesis GO:0048588 developmental cell growth GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048596 embryonic camera-type eye morphogenesis GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048644 muscle organ morphogenesis GO:0048645 animal organ formation GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048706 embryonic skeletal system development GO:0048732 gland development GO:0048736 appendage development GO:0048738 cardiac muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048806 genitalia development GO:0048839 inner ear development GO:0048841 regulation of axon extension involved in axon guidance GO:0048843 negative regulation of axon extension involved in axon guidance GO:0048846 axon extension involved in axon guidance GO:0048850 hypophysis morphogenesis GO:0048852 diencephalon morphogenesis GO:0048853 forebrain morphogenesis GO:0048854 brain morphogenesis GO:0050663 cytokine secretion GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050701 interleukin-1 secretion GO:0050702 interleukin-1 beta secretion GO:0050704 regulation of interleukin-1 secretion GO:0050706 regulation of interleukin-1 beta secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050716 positive regulation of interleukin-1 secretion GO:0050718 positive regulation of interleukin-1 beta secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050755 chemokine metabolic process GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050771 negative regulation of axonogenesis GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0050919 negative chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050922 negative regulation of chemotaxis GO:0051047 positive regulation of secretion GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051216 cartilage development GO:0051222 positive regulation of protein transport GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051321 meiotic cell cycle GO:0051403 stress-activated MAPK cascade GO:0051445 regulation of meiotic cell cycle GO:0051446 positive regulation of meiotic cell cycle GO:0051592 response to calcium ion GO:0051783 regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051964 negative regulation of synapse assembly GO:0055008 cardiac muscle tissue morphogenesis GO:0055123 digestive system development GO:0060021 palate development GO:0060026 convergent extension GO:0060027 convergent extension involved in gastrulation GO:0060028 convergent extension involved in axis elongation GO:0060029 convergent extension involved in organogenesis GO:0060031 mediolateral intercalation GO:0060039 pericardium development GO:0060065 uterus development GO:0060067 cervix development GO:0060068 vagina development GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060157 urinary bladder development GO:0060173 limb development GO:0060324 face development GO:0060326 cell chemotaxis GO:0060337 type I interferon signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway GO:0060340 positive regulation of type I interferon-mediated signaling pathway GO:0060411 cardiac septum morphogenesis GO:0060412 ventricular septum morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060443 mammary gland morphogenesis GO:0060444 branching involved in mammary gland duct morphogenesis GO:0060485 mesenchyme development GO:0060512 prostate gland morphogenesis GO:0060513 prostatic bud formation GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060571 morphogenesis of an epithelial fold GO:0060572 morphogenesis of an epithelial bud GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis GO:0060601 lateral sprouting from an epithelium GO:0060602 branch elongation of an epithelium GO:0060603 mammary gland duct morphogenesis GO:0060606 tube closure GO:0060627 regulation of vesicle-mediated transport GO:0060638 mesenchymal-epithelial cell signaling GO:0060685 regulation of prostatic bud formation GO:0060686 negative regulation of prostatic bud formation GO:0060688 regulation of morphogenesis of a branching structure GO:0060740 prostate gland epithelium morphogenesis GO:0060744 mammary gland branching involved in thelarche GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation GO:0060751 branch elongation involved in mammary gland duct branching GO:0060759 regulation of response to cytokine stimulus GO:0060760 positive regulation of response to cytokine stimulus GO:0060762 regulation of branching involved in mammary gland duct morphogenesis GO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation GO:0060809 mesodermal to mesenchymal transition involved in gastrulation GO:0060828 regulation of canonical Wnt signaling pathway GO:0060900 embryonic camera-type eye formation GO:0060907 positive regulation of macrophage cytokine production GO:0061035 regulation of cartilage development GO:0061036 positive regulation of cartilage development GO:0061053 somite development GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061082 myeloid leukocyte cytokine production GO:0061138 morphogenesis of a branching epithelium GO:0061162 establishment of monopolar cell polarity GO:0061180 mammary gland epithelium development GO:0061245 establishment or maintenance of bipolar cell polarity GO:0061311 cell surface receptor signaling pathway involved in heart development GO:0061339 establishment or maintenance of monopolar cell polarity GO:0061341 non-canonical Wnt signaling pathway involved in heart development GO:0061346 planar cell polarity pathway involved in heart morphogenesis GO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis GO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061351 neural precursor cell proliferation GO:0061354 planar cell polarity pathway involved in pericardium morphogenesis GO:0061371 determination of heart left/right asymmetry GO:0061387 regulation of extent of cell growth GO:0061448 connective tissue development GO:0061458 reproductive system development GO:0061525 hindgut development GO:0061564 axon development GO:0061642 chemoattraction of axon GO:0061643 chemorepulsion of axon GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070230 positive regulation of lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070232 regulation of T cell apoptotic process GO:0070234 positive regulation of T cell apoptotic process GO:0070242 thymocyte apoptotic process GO:0070243 regulation of thymocyte apoptotic process GO:0070245 positive regulation of thymocyte apoptotic process GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070528 protein kinase C signaling GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071229 cellular response to acid chemical GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071277 cellular response to calcium ion GO:0071300 cellular response to retinoic acid GO:0071346 cellular response to interferon-gamma GO:0071357 cellular response to type I interferon GO:0071396 cellular response to lipid GO:0071425 hematopoietic stem cell proliferation GO:0071542 dopaminergic neuron differentiation GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0071774 response to fibroblast growth factor GO:0071887 leukocyte apoptotic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072001 renal system development GO:0072089 stem cell proliferation GO:0072132 mesenchyme morphogenesis GO:0072175 epithelial tube formation GO:0072201 negative regulation of mesenchymal cell proliferation GO:0072606 interleukin-8 secretion GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0090009 primitive streak formation GO:0090036 regulation of protein kinase C signaling GO:0090037 positive regulation of protein kinase C signaling GO:0090066 regulation of anatomical structure size GO:0090068 positive regulation of cell cycle process GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090102 cochlea development GO:0090103 cochlea morphogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090162 establishment of epithelial cell polarity GO:0090175 regulation of establishment of planar polarity GO:0090177 establishment of planar polarity involved in neural tube closure GO:0090178 regulation of establishment of planar polarity involved in neural tube closure GO:0090179 planar cell polarity pathway involved in neural tube closure GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:0090596 sensory organ morphogenesis GO:0090630 activation of GTPase activity GO:0097325 melanocyte proliferation GO:0097485 neuron projection guidance GO:0099054 presynapse assembly GO:0099068 postsynapse assembly GO:0198738 cell-cell signaling by wnt GO:1900019 regulation of protein kinase C activity GO:1900020 positive regulation of protein kinase C activity GO:1900376 regulation of secondary metabolite biosynthetic process GO:1900377 negative regulation of secondary metabolite biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901342 regulation of vasculature development GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1901623 regulation of lymphocyte chemotaxis GO:1902284 neuron projection extension involved in neuron projection guidance GO:1902473 regulation of protein localization to synapse GO:1902474 positive regulation of protein localization to synapse GO:1902667 regulation of axon guidance GO:1902668 negative regulation of axon guidance GO:1903046 meiotic cell cycle process GO:1903532 positive regulation of secretion by cell GO:1904018 positive regulation of vasculature development GO:1904861 excitatory synapse assembly GO:1904862 inhibitory synapse assembly GO:1904933 regulation of cell proliferation in midbrain GO:1904934 negative regulation of cell proliferation in midbrain GO:1904938 planar cell polarity pathway involved in axon guidance GO:1904948 midbrain dopaminergic neuron differentiation GO:1904951 positive regulation of establishment of protein localization GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1904955 planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation GO:1905276 regulation of epithelial tube formation GO:1905330 regulation of morphogenesis of an epithelium GO:1905331 negative regulation of morphogenesis of an epithelium GO:1905438 non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation GO:1990138 neuron projection extension GO:2000027 regulation of organ morphogenesis GO:2000047 regulation of cell-cell adhesion mediated by cadherin GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin GO:2000050 regulation of non-canonical Wnt signaling pathway GO:2000052 positive regulation of non-canonical Wnt signaling pathway GO:2000106 regulation of leukocyte apoptotic process GO:2000108 positive regulation of leukocyte apoptotic process GO:2000147 positive regulation of cell motility GO:2000177 regulation of neural precursor cell proliferation GO:2000178 negative regulation of neural precursor cell proliferation GO:2000241 regulation of reproductive process GO:2000242 negative regulation of reproductive process GO:2000243 positive regulation of reproductive process GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration GO:2000482 regulation of interleukin-8 secretion GO:2000484 positive regulation of interleukin-8 secretion |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005109 frizzled binding GO:0005110 frizzled-2 binding GO:0005115 receptor tyrosine kinase-like orphan receptor binding GO:0005125 cytokine activity GO:0030545 receptor regulator activity GO:0030546 receptor activator activity GO:0042056 chemoattractant activity GO:0048018 receptor agonist activity GO:1902379 chemoattractant activity involved in axon guidance |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005788 endoplasmic reticulum lumen GO:0005796 Golgi lumen GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0045334 clathrin-coated endocytic vesicle |
KEGG |
hsa04150 mTOR signaling pathway hsa04310 Wnt signaling pathway hsa04360 Axon guidance hsa04390 Hippo signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04916 Melanogenesis |
Reactome |
R-HSA-4608870: Asymmetric localization of PCP proteins R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-4086398: Ca2+ pathway R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-500792: GPCR ligand binding R-HSA-199991: Membrane Trafficking R-HSA-3772470: Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-4086400: PCP/CE pathway R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-5653656: Vesicle-mediated transport R-HSA-3238698: WNT ligand biogenesis and trafficking R-HSA-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5099900: WNT5A-dependent internalization of FZD4 |
Summary | |
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Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between WNT5A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between WNT5A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of WNT5A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of WNT5A in various data sets.
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Points in the above scatter plot represent the mutation difference of WNT5A in various data sets.
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Summary | |
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Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WNT5A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WNT5A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WNT5A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WNT5A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of WNT5A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | WNT5A |
Name | wingless-type MMTV integration site family, member 5A |
Aliases | hWNT5A; WNT-5A protein; Protein Wnt-5a |
Chromosomal Location | 3p21-p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between WNT5A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |