Browse WNT5A

Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix Secreted
Domain PF00110 wnt family
Function

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0000578 embryonic axis specification
GO:0001101 response to acid chemical
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001667 ameboidal-type cell migration
GO:0001702 gastrulation with mouth forming second
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001756 somitogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001819 positive regulation of cytokine production
GO:0001837 epithelial to mesenchymal transition
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001947 heart looping
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002011 morphogenesis of an epithelial sheet
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002064 epithelial cell development
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002066 columnar/cuboidal epithelial cell development
GO:0002067 glandular epithelial cell differentiation
GO:0002068 glandular epithelial cell development
GO:0002072 optic cup morphogenesis involved in camera-type eye development
GO:0002088 lens development in camera-type eye
GO:0002237 response to molecule of bacterial origin
GO:0002274 myeloid leukocyte activation
GO:0002367 cytokine production involved in immune response
GO:0002374 cytokine secretion involved in immune response
GO:0002440 production of molecular mediator of immune response
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002700 regulation of production of molecular mediator of immune response
GO:0002702 positive regulation of production of molecular mediator of immune response
GO:0002718 regulation of cytokine production involved in immune response
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002739 regulation of cytokine secretion involved in immune response
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003143 embryonic heart tube morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003156 regulation of animal organ formation
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003213 cardiac right atrium morphogenesis
GO:0003230 cardiac atrium development
GO:0003231 cardiac ventricle development
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0003306 Wnt signaling pathway involved in heart development
GO:0003309 type B pancreatic cell differentiation
GO:0003323 type B pancreatic cell development
GO:0003344 pericardium morphogenesis
GO:0003401 axis elongation
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0003408 optic cup formation involved in camera-type eye development
GO:0006140 regulation of nucleotide metabolic process
GO:0006582 melanin metabolic process
GO:0007126 meiotic nuclear division
GO:0007163 establishment or maintenance of cell polarity
GO:0007164 establishment of tissue polarity
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0007350 blastoderm segmentation
GO:0007351 tripartite regional subdivision
GO:0007368 determination of left/right symmetry
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007423 sensory organ development
GO:0007442 hindgut morphogenesis
GO:0007494 midgut development
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007548 sex differentiation
GO:0008361 regulation of cell size
GO:0008406 gonad development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0008584 male gonad development
GO:0008595 anterior/posterior axis specification, embryo
GO:0009150 purine ribonucleotide metabolic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009306 protein secretion
GO:0009798 axis specification
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009880 embryonic pattern specification
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009913 epidermal cell differentiation
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010463 mesenchymal cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010799 regulation of peptidyl-threonine phosphorylation
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010818 T cell chemotaxis
GO:0010819 regulation of T cell chemotaxis
GO:0010820 positive regulation of T cell chemotaxis
GO:0010934 macrophage cytokine production
GO:0010935 regulation of macrophage cytokine production
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0014020 primary neural tube formation
GO:0014706 striated muscle tissue development
GO:0016049 cell growth
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0018958 phenol-containing compound metabolic process
GO:0019748 secondary metabolic process
GO:0021536 diencephalon development
GO:0021537 telencephalon development
GO:0021772 olfactory bulb development
GO:0021872 forebrain generation of neurons
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0021889 olfactory bulb interneuron differentiation
GO:0021891 olfactory bulb interneuron development
GO:0021915 neural tube development
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0021983 pituitary gland development
GO:0021988 olfactory lobe development
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022604 regulation of cell morphogenesis
GO:0022612 gland morphogenesis
GO:0030010 establishment of cell polarity
GO:0030100 regulation of endocytosis
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030216 keratinocyte differentiation
GO:0030278 regulation of ossification
GO:0030308 negative regulation of cell growth
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030335 positive regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030516 regulation of axon extension
GO:0030517 negative regulation of axon extension
GO:0030540 female genitalia development
GO:0030595 leukocyte chemotaxis
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030823 regulation of cGMP metabolic process
GO:0030825 positive regulation of cGMP metabolic process
GO:0030850 prostate gland development
GO:0030859 polarized epithelial cell differentiation
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030903 notochord development
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0031076 embryonic camera-type eye development
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031345 negative regulation of cell projection organization
GO:0031346 positive regulation of cell projection organization
GO:0031349 positive regulation of defense response
GO:0032092 positive regulation of protein binding
GO:0032102 negative regulation of response to external stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032496 response to lipopolysaccharide
GO:0032526 response to retinoic acid
GO:0032535 regulation of cellular component size
GO:0032602 chemokine production
GO:0032609 interferon-gamma production
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032635 interleukin-6 production
GO:0032637 interleukin-8 production
GO:0032642 regulation of chemokine production
GO:0032649 regulation of interferon-gamma production
GO:0032651 regulation of interleukin-1 beta production
GO:0032652 regulation of interleukin-1 production
GO:0032675 regulation of interleukin-6 production
GO:0032677 regulation of interleukin-8 production
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033278 cell proliferation in midbrain
GO:0033598 mammary gland epithelial cell proliferation
GO:0033674 positive regulation of kinase activity
GO:0034340 response to type I interferon
GO:0034341 response to interferon-gamma
GO:0035050 embryonic heart tube development
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035089 establishment of apical/basal cell polarity
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035270 endocrine system development
GO:0035282 segmentation
GO:0035418 protein localization to synapse
GO:0035567 non-canonical Wnt signaling pathway
GO:0035883 enteroendocrine cell differentiation
GO:0036342 post-anal tail morphogenesis
GO:0036514 dopaminergic neuron axon guidance
GO:0036515 serotonergic neuron axon guidance
GO:0036517 chemoattraction of serotonergic neuron axon
GO:0036518 chemorepulsion of dopaminergic neuron axon
GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0040013 negative regulation of locomotion
GO:0040017 positive regulation of locomotion
GO:0040020 regulation of meiotic nuclear division
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042033 chemokine biosynthetic process
GO:0042035 regulation of cytokine biosynthetic process
GO:0042074 cell migration involved in gastrulation
GO:0042089 cytokine biosynthetic process
GO:0042107 cytokine metabolic process
GO:0042108 positive regulation of cytokine biosynthetic process
GO:0042116 macrophage activation
GO:0042176 regulation of protein catabolic process
GO:0042249 establishment of planar polarity of embryonic epithelium
GO:0042438 melanin biosynthetic process
GO:0042440 pigment metabolic process
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042695 thelarche
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0043030 regulation of macrophage activation
GO:0043032 positive regulation of macrophage activation
GO:0043393 regulation of protein binding
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043455 regulation of secondary metabolic process
GO:0043506 regulation of JUN kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0043542 endothelial cell migration
GO:0043583 ear development
GO:0043588 skin development
GO:0044331 cell-cell adhesion mediated by cadherin
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044550 secondary metabolite biosynthetic process
GO:0045073 regulation of chemokine biosynthetic process
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045136 development of secondary sexual characteristics
GO:0045137 development of primary sexual characteristics
GO:0045165 cell fate commitment
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045778 positive regulation of ossification
GO:0045785 positive regulation of cell adhesion
GO:0045787 positive regulation of cell cycle
GO:0045807 positive regulation of endocytosis
GO:0045836 positive regulation of meiotic nuclear division
GO:0045860 positive regulation of protein kinase activity
GO:0045926 negative regulation of growth
GO:0045981 positive regulation of nucleotide metabolic process
GO:0045992 negative regulation of embryonic development
GO:0045995 regulation of embryonic development
GO:0046068 cGMP metabolic process
GO:0046148 pigment biosynthetic process
GO:0046189 phenol-containing compound biosynthetic process
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046543 development of secondary female sexual characteristics
GO:0046546 development of primary male sexual characteristics
GO:0046660 female sex differentiation
GO:0046661 male sex differentiation
GO:0048021 regulation of melanin biosynthetic process
GO:0048022 negative regulation of melanin biosynthetic process
GO:0048048 embryonic eye morphogenesis
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048247 lymphocyte chemotaxis
GO:0048332 mesoderm morphogenesis
GO:0048339 paraxial mesoderm development
GO:0048340 paraxial mesoderm morphogenesis
GO:0048341 paraxial mesoderm formation
GO:0048514 blood vessel morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048570 notochord morphogenesis
GO:0048588 developmental cell growth
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048608 reproductive structure development
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048644 muscle organ morphogenesis
GO:0048645 animal organ formation
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0048706 embryonic skeletal system development
GO:0048732 gland development
GO:0048736 appendage development
GO:0048738 cardiac muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048806 genitalia development
GO:0048839 inner ear development
GO:0048841 regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048846 axon extension involved in axon guidance
GO:0048850 hypophysis morphogenesis
GO:0048852 diencephalon morphogenesis
GO:0048853 forebrain morphogenesis
GO:0048854 brain morphogenesis
GO:0050663 cytokine secretion
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050701 interleukin-1 secretion
GO:0050702 interleukin-1 beta secretion
GO:0050704 regulation of interleukin-1 secretion
GO:0050706 regulation of interleukin-1 beta secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050716 positive regulation of interleukin-1 secretion
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050755 chemokine metabolic process
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050803 regulation of synapse structure or activity
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050900 leukocyte migration
GO:0050918 positive chemotaxis
GO:0050919 negative chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050922 negative regulation of chemotaxis
GO:0051047 positive regulation of secretion
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051216 cartilage development
GO:0051222 positive regulation of protein transport
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051321 meiotic cell cycle
GO:0051403 stress-activated MAPK cascade
GO:0051445 regulation of meiotic cell cycle
GO:0051446 positive regulation of meiotic cell cycle
GO:0051592 response to calcium ion
GO:0051783 regulation of nuclear division
GO:0051785 positive regulation of nuclear division
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0051963 regulation of synapse assembly
GO:0051964 negative regulation of synapse assembly
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055123 digestive system development
GO:0060021 palate development
GO:0060026 convergent extension
GO:0060027 convergent extension involved in gastrulation
GO:0060028 convergent extension involved in axis elongation
GO:0060029 convergent extension involved in organogenesis
GO:0060031 mediolateral intercalation
GO:0060039 pericardium development
GO:0060065 uterus development
GO:0060067 cervix development
GO:0060068 vagina development
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060157 urinary bladder development
GO:0060173 limb development
GO:0060324 face development
GO:0060326 cell chemotaxis
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060443 mammary gland morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060485 mesenchyme development
GO:0060512 prostate gland morphogenesis
GO:0060513 prostatic bud formation
GO:0060537 muscle tissue development
GO:0060541 respiratory system development
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060571 morphogenesis of an epithelial fold
GO:0060572 morphogenesis of an epithelial bud
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis
GO:0060601 lateral sprouting from an epithelium
GO:0060602 branch elongation of an epithelium
GO:0060603 mammary gland duct morphogenesis
GO:0060606 tube closure
GO:0060627 regulation of vesicle-mediated transport
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060685 regulation of prostatic bud formation
GO:0060686 negative regulation of prostatic bud formation
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060740 prostate gland epithelium morphogenesis
GO:0060744 mammary gland branching involved in thelarche
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0060751 branch elongation involved in mammary gland duct branching
GO:0060759 regulation of response to cytokine stimulus
GO:0060760 positive regulation of response to cytokine stimulus
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation
GO:0060809 mesodermal to mesenchymal transition involved in gastrulation
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060900 embryonic camera-type eye formation
GO:0060907 positive regulation of macrophage cytokine production
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061053 somite development
GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response
GO:0061082 myeloid leukocyte cytokine production
GO:0061138 morphogenesis of a branching epithelium
GO:0061162 establishment of monopolar cell polarity
GO:0061180 mammary gland epithelium development
GO:0061245 establishment or maintenance of bipolar cell polarity
GO:0061311 cell surface receptor signaling pathway involved in heart development
GO:0061339 establishment or maintenance of monopolar cell polarity
GO:0061341 non-canonical Wnt signaling pathway involved in heart development
GO:0061346 planar cell polarity pathway involved in heart morphogenesis
GO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0061354 planar cell polarity pathway involved in pericardium morphogenesis
GO:0061371 determination of heart left/right asymmetry
GO:0061387 regulation of extent of cell growth
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0061525 hindgut development
GO:0061564 axon development
GO:0061642 chemoattraction of axon
GO:0061643 chemorepulsion of axon
GO:0070227 lymphocyte apoptotic process
GO:0070228 regulation of lymphocyte apoptotic process
GO:0070230 positive regulation of lymphocyte apoptotic process
GO:0070231 T cell apoptotic process
GO:0070232 regulation of T cell apoptotic process
GO:0070234 positive regulation of T cell apoptotic process
GO:0070242 thymocyte apoptotic process
GO:0070243 regulation of thymocyte apoptotic process
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070528 protein kinase C signaling
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071229 cellular response to acid chemical
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071277 cellular response to calcium ion
GO:0071300 cellular response to retinoic acid
GO:0071346 cellular response to interferon-gamma
GO:0071357 cellular response to type I interferon
GO:0071396 cellular response to lipid
GO:0071425 hematopoietic stem cell proliferation
GO:0071542 dopaminergic neuron differentiation
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0071774 response to fibroblast growth factor
GO:0071887 leukocyte apoptotic process
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072089 stem cell proliferation
GO:0072132 mesenchyme morphogenesis
GO:0072175 epithelial tube formation
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0072606 interleukin-8 secretion
GO:0072676 lymphocyte migration
GO:0072678 T cell migration
GO:0090009 primitive streak formation
GO:0090036 regulation of protein kinase C signaling
GO:0090037 positive regulation of protein kinase C signaling
GO:0090066 regulation of anatomical structure size
GO:0090068 positive regulation of cell cycle process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090102 cochlea development
GO:0090103 cochlea morphogenesis
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090162 establishment of epithelial cell polarity
GO:0090175 regulation of establishment of planar polarity
GO:0090177 establishment of planar polarity involved in neural tube closure
GO:0090178 regulation of establishment of planar polarity involved in neural tube closure
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0090596 sensory organ morphogenesis
GO:0090630 activation of GTPase activity
GO:0097325 melanocyte proliferation
GO:0097485 neuron projection guidance
GO:0099054 presynapse assembly
GO:0099068 postsynapse assembly
GO:0198738 cell-cell signaling by wnt
GO:1900019 regulation of protein kinase C activity
GO:1900020 positive regulation of protein kinase C activity
GO:1900376 regulation of secondary metabolite biosynthetic process
GO:1900377 negative regulation of secondary metabolite biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901342 regulation of vasculature development
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1901623 regulation of lymphocyte chemotaxis
GO:1902284 neuron projection extension involved in neuron projection guidance
GO:1902473 regulation of protein localization to synapse
GO:1902474 positive regulation of protein localization to synapse
GO:1902667 regulation of axon guidance
GO:1902668 negative regulation of axon guidance
GO:1903046 meiotic cell cycle process
GO:1903532 positive regulation of secretion by cell
GO:1904018 positive regulation of vasculature development
GO:1904861 excitatory synapse assembly
GO:1904862 inhibitory synapse assembly
GO:1904933 regulation of cell proliferation in midbrain
GO:1904934 negative regulation of cell proliferation in midbrain
GO:1904938 planar cell polarity pathway involved in axon guidance
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904951 positive regulation of establishment of protein localization
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1904955 planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
GO:1905276 regulation of epithelial tube formation
GO:1905330 regulation of morphogenesis of an epithelium
GO:1905331 negative regulation of morphogenesis of an epithelium
GO:1905438 non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1990138 neuron projection extension
GO:2000027 regulation of organ morphogenesis
GO:2000047 regulation of cell-cell adhesion mediated by cadherin
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000050 regulation of non-canonical Wnt signaling pathway
GO:2000052 positive regulation of non-canonical Wnt signaling pathway
GO:2000106 regulation of leukocyte apoptotic process
GO:2000108 positive regulation of leukocyte apoptotic process
GO:2000147 positive regulation of cell motility
GO:2000177 regulation of neural precursor cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000241 regulation of reproductive process
GO:2000242 negative regulation of reproductive process
GO:2000243 positive regulation of reproductive process
GO:2000401 regulation of lymphocyte migration
GO:2000403 positive regulation of lymphocyte migration
GO:2000404 regulation of T cell migration
GO:2000406 positive regulation of T cell migration
GO:2000482 regulation of interleukin-8 secretion
GO:2000484 positive regulation of interleukin-8 secretion
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0005109 frizzled binding
GO:0005110 frizzled-2 binding
GO:0005115 receptor tyrosine kinase-like orphan receptor binding
GO:0005125 cytokine activity
GO:0030545 receptor regulator activity
GO:0030546 receptor activator activity
GO:0042056 chemoattractant activity
GO:0048018 receptor agonist activity
GO:1902379 chemoattractant activity involved in axon guidance
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030662 coated vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0045334 clathrin-coated endocytic vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04150 mTOR signaling pathway
hsa04310 Wnt signaling pathway
hsa04360 Axon guidance
hsa04390 Hippo signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04916 Melanogenesis
Reactome R-HSA-4608870: Asymmetric localization of PCP proteins
R-HSA-3858494: Beta-catenin independent WNT signaling
R-HSA-4086398: Ca2+ pathway
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-500792: GPCR ligand binding
R-HSA-199991: Membrane Trafficking
R-HSA-3772470: Negative regulation of TCF-dependent signaling by WNT ligand antagonists
R-HSA-4086400: PCP/CE pathway
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-5653656: Vesicle-mediated transport
R-HSA-3238698: WNT ligand biogenesis and trafficking
R-HSA-5140745: WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-5099900: WNT5A-dependent internalization of FZD4
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between WNT5A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between WNT5A and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26041736MelanomaInhibit immunity (T cell function)Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy.
29370526MelanomaInhibit immunity (infiltration); Resistant to immunotherapyNanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B-Raf Proto-Oncogene Mutant Melanoma. Wnt family member 5A (Wnt5a), a signaling protein highly produced by BRAF mutant melanoma cells, has been implicated in inducing dendritic cell tolerance and tumor fibrosis, thus hindering effective antigen presentation and T-cell infiltration. We hypothesized that Wnt5a is a key molecule controlling the immunosuppressive tumor microenvironment in metastatic melanoma. Our findings indicated that efficient local Wnt5a trapping significantly remodeled the immunosuppressive tumor microenvironment to facilitate immunogenic cell-death-mediated immunotherapy.
28465528Chronic Lymphocytic LeukemiaInhibit immunity (T cell function)Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells. Wnt5a can activate Rho GTPases in chronic lymphocytic leukemia (CLL) cells by inducing the recruitment of ARHGEF2 to ROR1. The capacity of Wnt5a to induce ROR1 to complex with 14-3-3ζ could be blocked in CLL cells by treatment with cirmtuzumab, a humanized mAb targeting ROR1.
19074888MelanomaInhibit immunity (T cell function)Melanosomal antigen expression is governed by MITF, PAX3, and SOX10 and is inhibited upon signal transducers and activators of transcription 3 (STAT3) activation, via decreases in PAX3 and subsequently MITF expression. Increasing Wnt5A in Wnt5A-low cells activated STAT3, and STAT3 was decreased upon Wnt5A knockdown. CTL activation studies showed that increases in Wnt5A correspond to decreased CTL activation and vice versa, suggesting that targeting Wnt5A before immunotherapy may lead to the enhancement of current targeted immunotherapy for patients with metastatic melanoma.
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of WNT5A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of WNT5A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0480.0284
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.1790.0063
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2280.762
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1730.777
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7690.686
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5750.801
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0320.957
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3220.772
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4530.699
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0330.334
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.9070.175
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2780.164
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of WNT5A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WNT5A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WNT5A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WNT5A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WNT5A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of WNT5A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between WNT5A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolWNT5A
Namewingless-type MMTV integration site family, member 5A
Aliases hWNT5A; WNT-5A protein; Protein Wnt-5a
Chromosomal Location3p21-p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting WNT5A collected from DrugBank database.
> Drugs from DrugBank database
 

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