Browse WWTR1

Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15.
Domain PF00397 WW domain
Function

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001933 negative regulation of protein phosphorylation
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007184 SMAD protein import into nucleus
GO:0010498 proteasomal protein catabolic process
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016055 Wnt signaling pathway
GO:0017038 protein import
GO:0017145 stem cell division
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030856 regulation of epithelial cell differentiation
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032835 glomerulus development
GO:0033157 regulation of intracellular protein transport
GO:0033673 negative regulation of kinase activity
GO:0034504 protein localization to nucleus
GO:0035264 multicellular organism growth
GO:0035329 hippo signaling
GO:0035411 catenin import into nucleus
GO:0035412 regulation of catenin import into nucleus
GO:0035414 negative regulation of catenin import into nucleus
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0042306 regulation of protein import into nucleus
GO:0042308 negative regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044744 protein targeting to nucleus
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046823 negative regulation of nucleocytoplasmic transport
GO:0048762 mesenchymal cell differentiation
GO:0051051 negative regulation of transport
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051224 negative regulation of protein transport
GO:0051348 negative regulation of transferase activity
GO:0060070 canonical Wnt signaling pathway
GO:0060271 cilium morphogenesis
GO:0060390 regulation of SMAD protein import into nucleus
GO:0060485 mesenchyme development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060993 kidney morphogenesis
GO:0061005 cell differentiation involved in kidney development
GO:0061326 renal tubule development
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072073 kidney epithelium development
GO:0072080 nephron tubule development
GO:0072160 nephron tubule epithelial cell differentiation
GO:0072170 metanephric tubule development
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0072202 cell differentiation involved in metanephros development
GO:0072207 metanephric epithelium development
GO:0072215 regulation of metanephros development
GO:0072234 metanephric nephron tubule development
GO:0072243 metanephric nephron epithelium development
GO:0072257 metanephric nephron tubule epithelial cell differentiation
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090183 regulation of kidney development
GO:0090317 negative regulation of intracellular protein transport
GO:0198738 cell-cell signaling by wnt
GO:1900180 regulation of protein localization to nucleus
GO:1900181 negative regulation of protein localization to nucleus
GO:1902593 single-organism nuclear import
GO:1903533 regulation of protein targeting
GO:1903828 negative regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904590 negative regulation of protein import
GO:1904950 negative regulation of establishment of protein localization
GO:2000696 regulation of epithelial cell differentiation involved in kidney development
Molecular Function GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
Cellular Component GO:0005667 transcription factor complex
> KEGG and Reactome Pathway
 
KEGG hsa04390 Hippo signaling pathway
Reactome R-HSA-5576891: Cardiac conduction
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-397014: Muscle contraction
R-HSA-1989781: PPARA activates gene expression
R-HSA-5578768: Physiological factors
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-2173796: SMAD2/SMAD3
R-HSA-162582: Signal Transduction
R-HSA-2028269: Signaling by Hippo
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression
Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between WWTR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of WWTR1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.59 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of WWTR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3250.491
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2580.906
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3790.823
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1290.752
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2650.909
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0420.989
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0870.879
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4720.824
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4390.844
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0530.978
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8660.75
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4120.000979
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of WWTR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277304.1-4.10.561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275905.1-5.10.549
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WWTR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WWTR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WWTR1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WWTR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of WWTR1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between WWTR1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolWWTR1
NameWW domain containing transcription regulator 1
Aliases DKFZp586I1419; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-bin ......
Chromosomal Location3q23-q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting WWTR1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.