Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). ; SUBCELLULAR LOCATION: Isoform 1: Nucleus Cytoplasm Endoplasmic reticulum membrane Single-pass type II membrane protein Endoplasmic reticulum membrane Peripheral membrane protein Membrane Peripheral membrane protein Note=Shows no preferential localization to either the nucleus or the cytoplasm (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:16461360). Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (PubMed:19394296, PubMed:25190803). ; SUBCELLULAR LOCATION: Isoform 2: Nucleus Cytoplasm Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (By similarity). ; SUBCELLULAR LOCATION: X-box-binding protein 1, cytoplasmic form: Cytoplasm Nucleus Note=Localizes in the cytoplasm and nucleus after HM13/SPP-mediated intramembranaire proteolytic cleavage of isoform 1 (PubMed:25239945). |
Domain |
PF07716 Basic region leucine zipper |
Function |
Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). ; FUNCTION: Isoform 1: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ENR1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:2321018, PubMed:2196176, PubMed:1903538, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). ; FUNCTION: Isoform 2: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). |
Biological Process |
GO:0001101 response to acid chemical GO:0001525 angiogenesis GO:0001678 cellular glucose homeostasis GO:0001819 positive regulation of cytokine production GO:0001889 liver development GO:0001935 endothelial cell proliferation GO:0002064 epithelial cell development GO:0002070 epithelial cell maturation GO:0002237 response to molecule of bacterial origin GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002313 mature B cell differentiation involved in immune response GO:0002317 plasma cell differentiation GO:0002335 mature B cell differentiation GO:0002366 leukocyte activation involved in immune response GO:0002377 immunoglobulin production GO:0002440 production of molecular mediator of immune response GO:0002521 leukocyte differentiation GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006914 autophagy GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0007159 leukocyte cell-cell adhesion GO:0007431 salivary gland development GO:0007517 muscle organ development GO:0007584 response to nutrient GO:0007589 body fluid secretion GO:0007595 lactation GO:0009267 cellular response to starvation GO:0009306 protein secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009750 response to fructose GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009991 response to extracellular stimulus GO:0010498 proteasomal protein catabolic process GO:0010506 regulation of autophagy GO:0010830 regulation of myotube differentiation GO:0010832 negative regulation of myotube differentiation GO:0014902 myotube differentiation GO:0016053 organic acid biosynthetic process GO:0021700 developmental maturation GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022612 gland morphogenesis GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030217 T cell differentiation GO:0030335 positive regulation of cell migration GO:0030879 mammary gland development GO:0030968 endoplasmic reticulum unfolded protein response GO:0031016 pancreas development GO:0031017 exocrine pancreas development GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031647 regulation of protein stability GO:0031648 protein destabilization GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0032496 response to lipopolysaccharide GO:0032635 interleukin-6 production GO:0032675 regulation of interleukin-6 production GO:0032755 positive regulation of interleukin-6 production GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032941 secretion by tissue GO:0033500 carbohydrate homeostasis GO:0034284 response to monosaccharide GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035272 exocrine system development GO:0035356 cellular triglyceride homeostasis GO:0035470 positive regulation of vascular wound healing GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036498 IRE1-mediated unfolded protein response GO:0036500 ATF6-mediated unfolded protein response GO:0040017 positive regulation of locomotion GO:0042110 T cell activation GO:0042113 B cell activation GO:0042149 cellular response to glucose starvation GO:0042176 regulation of protein catabolic process GO:0042593 glucose homeostasis GO:0042594 response to starvation GO:0042632 cholesterol homeostasis GO:0042692 muscle cell differentiation GO:0043200 response to amino acid GO:0043434 response to peptide hormone GO:0044283 small molecule biosynthetic process GO:0045342 MHC class II biosynthetic process GO:0045346 regulation of MHC class II biosynthetic process GO:0045348 positive regulation of MHC class II biosynthetic process GO:0045444 fat cell differentiation GO:0045577 regulation of B cell differentiation GO:0045579 positive regulation of B cell differentiation GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045732 positive regulation of protein catabolic process GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045785 positive regulation of cell adhesion GO:0045862 positive regulation of proteolysis GO:0046394 carboxylic acid biosynthetic process GO:0048305 immunoglobulin secretion GO:0048469 cell maturation GO:0048514 blood vessel morphogenesis GO:0048732 gland development GO:0050663 cytokine secretion GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050871 positive regulation of B cell activation GO:0050878 regulation of body fluid levels GO:0051023 regulation of immunoglobulin secretion GO:0051024 positive regulation of immunoglobulin secretion GO:0051047 positive regulation of secretion GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051154 negative regulation of striated muscle cell differentiation GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0055088 lipid homeostasis GO:0055089 fatty acid homeostasis GO:0055090 acylglycerol homeostasis GO:0055092 sterol homeostasis GO:0055123 digestive system development GO:0060055 angiogenesis involved in wound healing GO:0060612 adipose tissue development GO:0060689 cell differentiation involved in salivary gland development GO:0060690 epithelial cell differentiation involved in salivary gland development GO:0060691 epithelial cell maturation involved in salivary gland development GO:0061008 hepaticobiliary system development GO:0061041 regulation of wound healing GO:0061042 vascular wound healing GO:0061043 regulation of vascular wound healing GO:0061136 regulation of proteasomal protein catabolic process GO:0061448 connective tissue development GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070328 triglyceride homeostasis GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070670 response to interleukin-4 GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071332 cellular response to fructose stimulus GO:0071333 cellular response to glucose stimulus GO:0071353 cellular response to interleukin-4 GO:0071375 cellular response to peptide hormone stimulus GO:0071396 cellular response to lipid GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:0071593 lymphocyte aggregation GO:0072330 monocarboxylic acid biosynthetic process GO:0072574 hepatocyte proliferation GO:0072575 epithelial cell proliferation involved in liver morphogenesis GO:0072576 liver morphogenesis GO:0072604 interleukin-6 secretion GO:0090303 positive regulation of wound healing GO:0097193 intrinsic apoptotic signaling pathway GO:1900098 regulation of plasma cell differentiation GO:1900100 positive regulation of plasma cell differentiation GO:1900101 regulation of endoplasmic reticulum unfolded protein response GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response GO:1901342 regulation of vasculature development GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901800 positive regulation of proteasomal protein catabolic process GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1903034 regulation of response to wounding GO:1903036 positive regulation of response to wounding GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903487 regulation of lactation GO:1903489 positive regulation of lactation GO:1903532 positive regulation of secretion by cell GO:1903573 negative regulation of response to endoplasmic reticulum stress GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1904018 positive regulation of vasculature development GO:1904951 positive regulation of establishment of protein localization GO:1990418 response to insulin-like growth factor stimulus GO:2000027 regulation of organ morphogenesis GO:2000147 positive regulation of cell motility GO:2000345 regulation of hepatocyte proliferation GO:2000347 positive regulation of hepatocyte proliferation GO:2000778 positive regulation of interleukin-6 secretion GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0001047 core promoter binding GO:0001085 RNA polymerase II transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0008134 transcription factor binding GO:0035326 enhancer binding GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding GO:0042826 histone deacetylase binding GO:0043548 phosphatidylinositol 3-kinase binding GO:0044389 ubiquitin-like protein ligase binding GO:0046982 protein heterodimerization activity |
Cellular Component | - |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome |
R-HSA-381183: ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones R-HSA-381070: IRE1alpha activates chaperones R-HSA-392499: Metabolism of proteins R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-381038: XBP1(S) activates chaperone genes |
Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between XBP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between XBP1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of XBP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of XBP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of XBP1 in various data sets.
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Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XBP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XBP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XBP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XBP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of XBP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between XBP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | XBP1 |
Name | X-box binding protein 1 |
Aliases | XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1 |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting XBP1 collected from DrugBank database. |
There is no record. |