Summary | |
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Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin. |
Biological Process |
GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0070098 chemokine-mediated signaling pathway GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis |
Molecular Function |
GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0004896 cytokine receptor activity GO:0004950 chemokine receptor activity GO:0008528 G-protein coupled peptide receptor activity |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between XCR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of XCR1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of XCR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of XCR1 in various data sets.
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Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XCR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XCR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XCR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XCR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of XCR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between XCR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | XCR1 |
Name | chemokine (C motif) receptor 1 |
Aliases | GPR5; CCXCR1; chemokine (C motif) XC receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; ...... |
Chromosomal Location | 3p21.3-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting XCR1 collected from DrugBank database. |
There is no record. |