Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction Note=Colocalizes with actin stress fibers. |
Domain |
PF08043 Xin repeat |
Function |
Protects actin filaments from depolymerization. |
Biological Process |
GO:0003007 heart morphogenesis GO:0003205 cardiac chamber development GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0007507 heart development GO:0007517 muscle organ development GO:0014706 striated muscle tissue development GO:0034330 cell junction organization GO:0045216 cell-cell junction organization GO:0048644 muscle organ morphogenesis GO:0048738 cardiac muscle tissue development GO:0055008 cardiac muscle tissue morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development |
Molecular Function |
GO:0003779 actin binding GO:0042805 actinin binding GO:0051393 alpha-actinin binding |
Cellular Component |
GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031674 I band GO:0043292 contractile fiber GO:0044449 contractile fiber part |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between XIRP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of XIRP2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of XIRP2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of XIRP2 in various data sets.
|
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XIRP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XIRP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XIRP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XIRP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of XIRP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between XIRP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | XIRP2 |
Name | xin actin binding repeat containing 2 |
Aliases | myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ...... |
Chromosomal Location | 2q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting XIRP2 collected from DrugBank database. |
There is no record. |