Browse XIRP2

Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell junction Note=Colocalizes with actin stress fibers.
Domain PF08043 Xin repeat
Function

Protects actin filaments from depolymerization.

> Gene Ontology
 
Biological Process GO:0003007 heart morphogenesis
GO:0003205 cardiac chamber development
GO:0003231 cardiac ventricle development
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0014706 striated muscle tissue development
GO:0034330 cell junction organization
GO:0045216 cell-cell junction organization
GO:0048644 muscle organ morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060537 muscle tissue development
Molecular Function GO:0003779 actin binding
GO:0042805 actinin binding
GO:0051393 alpha-actinin binding
Cellular Component GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0031674 I band
GO:0043292 contractile fiber
GO:0044449 contractile fiber part
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between XIRP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of XIRP2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of XIRP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0030.99
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1780.727
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1230.774
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0950.922
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6120.769
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.0010.658
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.9650.309
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.6950.261
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1180.95
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4050.545
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.4050.66
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2390.428
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of XIRP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.35.98.40.576
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277348.119.228.90.00561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 014028.6-28.61
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275948.116.931.20.00383
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117195.913.10.355
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.26.2160.53
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382718.418.5-0.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.223.1-4.91
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161418.814.34.51
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XIRP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XIRP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XIRP2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XIRP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of XIRP2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between XIRP2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolXIRP2
Namexin actin binding repeat containing 2
Aliases myomaxin; CMYA3; cardiomyopathy associated 3; beta-xin; cardiomyopathy-associated protein 3; xeplin; xin act ......
Chromosomal Location2q31.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting XIRP2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.