Browse XRCC1

Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage.
Domain PF00533 BRCA1 C Terminus (BRCT) domain
PF16589 BRCT domain
PF01834 XRCC1 N terminal domain
Function

Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.

> Gene Ontology
 
Biological Process GO:0000012 single strand break repair
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0001666 response to hypoxia
GO:0006266 DNA ligation
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006288 base-excision repair, DNA ligation
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021761 limbic system development
GO:0021766 hippocampus development
GO:0030900 forebrain development
GO:0036293 response to decreased oxygen levels
GO:0042493 response to drug
GO:0051103 DNA ligation involved in DNA repair
GO:0070482 response to oxygen levels
Molecular Function GO:0003684 damaged DNA binding
GO:0003909 DNA ligase activity
GO:0016874 ligase activity
GO:0016886 ligase activity, forming phosphoric ester bonds
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa03410 Base excision repair
Reactome R-HSA-5649702: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-73884: Base Excision Repair
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5685939: HDR through MMEJ (alt-NHEJ)
R-HSA-5693538: Homology Directed Repair
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-110381: Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-73933: Resolution of Abasic Sites (AP sites)
R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between XRCC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of XRCC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.54; FDR: 0.04180 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of XRCC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1450.514
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3340.869
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0080.996
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3790.137
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6840.741
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0080.998
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0960.748
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0380.977
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2060.891
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0310.982
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2330.908
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1540.0116
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of XRCC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.76.8-3.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 014014.3-14.31
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XRCC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XRCC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XRCC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XRCC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of XRCC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between XRCC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolXRCC1
NameX-ray repair complementing defective repair in Chinese hamster cells 1
Aliases RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting XRCC1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.