Summary | |
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Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage. |
Domain |
PF00533 BRCA1 C Terminus (BRCT) domain PF16589 BRCT domain PF01834 XRCC1 N terminal domain |
Function |
Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. |
Biological Process |
GO:0000012 single strand break repair GO:0000724 double-strand break repair via homologous recombination GO:0000725 recombinational repair GO:0001666 response to hypoxia GO:0006266 DNA ligation GO:0006283 transcription-coupled nucleotide-excision repair GO:0006284 base-excision repair GO:0006288 base-excision repair, DNA ligation GO:0006289 nucleotide-excision repair GO:0006297 nucleotide-excision repair, DNA gap filling GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0021537 telencephalon development GO:0021543 pallium development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0030900 forebrain development GO:0036293 response to decreased oxygen levels GO:0042493 response to drug GO:0051103 DNA ligation involved in DNA repair GO:0070482 response to oxygen levels |
Molecular Function |
GO:0003684 damaged DNA binding GO:0003909 DNA ligase activity GO:0016874 ligase activity GO:0016886 ligase activity, forming phosphoric ester bonds |
Cellular Component | - |
KEGG |
hsa03410 Base excision repair |
Reactome |
R-HSA-5649702: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-73884: Base Excision Repair R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5685939: HDR through MMEJ (alt-NHEJ) R-HSA-5693538: Homology Directed Repair R-HSA-5696398: Nucleotide Excision Repair R-HSA-110381: Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-73933: Resolution of Abasic Sites (AP sites) R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between XRCC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of XRCC1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of XRCC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of XRCC1 in various data sets.
|
Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XRCC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XRCC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XRCC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XRCC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of XRCC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between XRCC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | XRCC1 |
Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Aliases | RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1 |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting XRCC1 collected from DrugBank database. |
There is no record. |