Summary | |
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Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF02782 FGGY family of carbohydrate kinases PF00370 FGGY family of carbohydrate kinases |
Function |
Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0005997 xylulose metabolic process GO:0005998 xylulose catabolic process GO:0006063 uronic acid metabolic process GO:0006064 glucuronate catabolic process GO:0006091 generation of precursor metabolites and energy GO:0016052 carbohydrate catabolic process GO:0016054 organic acid catabolic process GO:0019321 pentose metabolic process GO:0019323 pentose catabolic process GO:0019585 glucuronate metabolic process GO:0019640 glucuronate catabolic process to xylulose 5-phosphate GO:0042732 D-xylose metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044282 small molecule catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046365 monosaccharide catabolic process GO:0046395 carboxylic acid catabolic process GO:0046835 carbohydrate phosphorylation GO:0051167 xylulose 5-phosphate metabolic process GO:0072329 monocarboxylic acid catabolic process GO:1901159 xylulose 5-phosphate biosynthetic process |
Molecular Function |
GO:0004856 xylulokinase activity GO:0019200 carbohydrate kinase activity |
Cellular Component | - |
KEGG |
hsa00040 Pentose and glucuronate interconversions hsa01100 Metabolic pathways |
Reactome |
R-HSA-5661270: Catabolism of glucuronate to xylulose-5-phosphate R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
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Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between XYLB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of XYLB in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of XYLB in various data sets.
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Points in the above scatter plot represent the mutation difference of XYLB in various data sets.
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Summary | |
---|---|
Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XYLB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XYLB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XYLB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XYLB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of XYLB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between XYLB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | XYLB |
Name | xylulokinase homolog (H. influenzae) |
Aliases | FLJ10343; FLJ12539; xylulokinase (H. influenzae) homolog; Xylulokinase; Xylulose kinase |
Chromosomal Location | 3p22-p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting XYLB collected from DrugBank database. |
There is no record. |