Browse YWHAZ

Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Melanosome Note=Located to stage I to stage IV melanosomes.
Domain PF00244 14-3-3 protein
Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

> Gene Ontology
 
Biological Process GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0006839 mitochondrial transport
GO:0007006 mitochondrial membrane organization
GO:0007030 Golgi organization
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008637 apoptotic mitochondrial changes
GO:0010608 posttranscriptional regulation of gene expression
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0030168 platelet activation
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0043487 regulation of RNA stability
GO:0043488 regulation of mRNA stability
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048308 organelle inheritance
GO:0048313 Golgi inheritance
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0051640 organelle localization
GO:0051645 Golgi localization
GO:0051656 establishment of organelle localization
GO:0051683 establishment of Golgi localization
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090168 Golgi reassembly
GO:0090559 regulation of membrane permeability
GO:0097345 mitochondrial outer membrane permeabilization
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Molecular Function GO:0008134 transcription factor binding
GO:0031625 ubiquitin protein ligase binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005913 cell-cell adherens junction
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
GO:0030659 cytoplasmic vesicle membrane
GO:0042470 melanosome
GO:0048770 pigment granule
GO:0072562 blood microparticle
> KEGG and Reactome Pathway
 
KEGG hsa04110 Cell cycle
hsa04114 Oocyte meiosis
hsa04151 PI3K-Akt signaling pathway
hsa04390 Hippo signaling pathway
Reactome R-HSA-111447: Activation of BAD and translocation to mitochondria
R-HSA-114452: Activation of BH3-only proteins
R-HSA-1280218: Adaptive Immune System
R-HSA-109581: Apoptosis
R-HSA-1640170: Cell Cycle
R-HSA-69620: Cell Cycle Checkpoints
R-HSA-75035: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-69481: G2/M Checkpoints
R-HSA-69473: G2/M DNA damage checkpoint
R-HSA-430116: GP1b-IX-V activation signalling
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-450604: KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-199991: Membrane Trafficking
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-5357801: Programmed Cell Death
R-HSA-195258: RHO GTPase Effectors
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-392517: Rap1 signalling
R-HSA-450531: Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-162582: Signal Transduction
R-HSA-449147: Signaling by Interleukins
R-HSA-194315: Signaling by Rho GTPases
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-5628897: TP53 Regulates Metabolic Genes
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between YWHAZ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of YWHAZ in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.60; FDR: 0.02000 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 4.17; FDR: 0.014 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of YWHAZ in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1170.63
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1510.969
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0890.974
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1380.677
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1470.956
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1320.971
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0090.988
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2150.938
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2090.946
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4040.868
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8220.827
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1510.133
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of YWHAZ in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of YWHAZ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of YWHAZ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by YWHAZ.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of YWHAZ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of YWHAZ expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between YWHAZ and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolYWHAZ
Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Aliases 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ......
Chromosomal Location8q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting YWHAZ collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting YWHAZ.
ID Name Drug Type Targets #Targets
DB12695Phenethyl IsothiocyanateSmall MoleculeACTA2, ACTB, ATP5B, ATP5I, ATP5L, CYB5B, DIABLO, FBXO41, HNRNPF, H ......45