Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Melanosome Note=Located to stage I to stage IV melanosomes. |
Domain |
PF00244 14-3-3 protein |
Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. |
Biological Process |
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0006839 mitochondrial transport GO:0007006 mitochondrial membrane organization GO:0007030 Golgi organization GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008637 apoptotic mitochondrial changes GO:0010608 posttranscriptional regulation of gene expression GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0030168 platelet activation GO:0035794 positive regulation of mitochondrial membrane permeability GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0046902 regulation of mitochondrial membrane permeability GO:0048308 organelle inheritance GO:0048313 Golgi inheritance GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051204 protein insertion into mitochondrial membrane GO:0051205 protein insertion into membrane GO:0051640 organelle localization GO:0051645 Golgi localization GO:0051656 establishment of organelle localization GO:0051683 establishment of Golgi localization GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0090168 Golgi reassembly GO:0090559 regulation of membrane permeability GO:0097345 mitochondrial outer membrane permeabilization GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway |
Molecular Function |
GO:0008134 transcription factor binding GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0030659 cytoplasmic vesicle membrane GO:0042470 melanosome GO:0048770 pigment granule GO:0072562 blood microparticle |
KEGG |
hsa04110 Cell cycle hsa04114 Oocyte meiosis hsa04151 PI3K-Akt signaling pathway hsa04390 Hippo signaling pathway |
Reactome |
R-HSA-111447: Activation of BAD and translocation to mitochondria R-HSA-114452: Activation of BH3-only proteins R-HSA-1280218: Adaptive Immune System R-HSA-109581: Apoptosis R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-75035: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-69481: G2/M Checkpoints R-HSA-69473: G2/M DNA damage checkpoint R-HSA-430116: GP1b-IX-V activation signalling R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-109606: Intrinsic Pathway for Apoptosis R-HSA-450604: KSRP (KHSRP) binds and destabilizes mRNA R-HSA-199991: Membrane Trafficking R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-5357801: Programmed Cell Death R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-392517: Rap1 signalling R-HSA-450531: Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-194315: Signaling by Rho GTPases R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-5628897: TP53 Regulates Metabolic Genes R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between YWHAZ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of YWHAZ in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of YWHAZ in various data sets.
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Points in the above scatter plot represent the mutation difference of YWHAZ in various data sets.
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Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of YWHAZ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of YWHAZ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by YWHAZ. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of YWHAZ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of YWHAZ expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between YWHAZ and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | YWHAZ |
Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Aliases | 14-3-3-zeta; 14-3-3 zeta; 14-3-3 delta; YWHAD; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatio ...... |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting YWHAZ collected from DrugBank database. |
Details on drugs targeting YWHAZ.
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