Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus matrix Note=Associated with the nuclear matrix. |
Domain | - |
Function |
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). ; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. |
Biological Process |
GO:0000724 double-strand break repair via homologous recombination GO:0000725 recombinational repair GO:0001654 eye development GO:0003002 regionalization GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0006403 RNA localization GO:0007283 spermatogenesis GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009952 anterior/posterior pattern specification GO:0010225 response to UV-C GO:0034644 cellular response to UV GO:0034694 response to prostaglandin GO:0034696 response to prostaglandin F GO:0043010 camera-type eye development GO:0048232 male gamete generation GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0070555 response to interleukin-1 GO:0071214 cellular response to abiotic stimulus GO:0071347 cellular response to interleukin-1 GO:0071478 cellular response to radiation GO:0071482 cellular response to light stimulus GO:0090596 sensory organ morphogenesis |
Molecular Function |
GO:0000217 DNA secondary structure binding GO:0000400 four-way junction DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001158 enhancer sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0035326 enhancer binding GO:0042826 histone deacetylase binding GO:0043566 structure-specific DNA binding GO:0046332 SMAD binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0016363 nuclear matrix GO:0031011 Ino80 complex GO:0031519 PcG protein complex GO:0033202 DNA helicase complex GO:0034399 nuclear periphery GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0097346 INO80-type complex |
KEGG | - |
Reactome |
R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5696394: DNA Damage Recognition in GG-NER R-HSA-73894: DNA Repair R-HSA-5688426: Deubiquitination R-HSA-1266738: Developmental Biology R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-392499: Metabolism of proteins R-HSA-5696398: Nucleotide Excision Repair R-HSA-597592: Post-translational protein modification R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-5689603: UCH proteinases |
Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between YY1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of YY1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of YY1 in various data sets.
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Points in the above scatter plot represent the mutation difference of YY1 in various data sets.
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Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of YY1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of YY1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by YY1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of YY1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of YY1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between YY1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | YY1 |
Name | YY1 transcription factor |
Aliases | UCRBP; YIN-YANG-1; INO80S; INO80 complex subunit S; Yin and Yang 1 protein; YY-1; delta transcription factor ...... |
Chromosomal Location | 14q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting YY1 collected from DrugBank database. |
There is no record. |