Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Nucleus, Nuclear body |
Domain |
PF00651 BTB/POZ domain |
Function |
Acts as a transcriptional repressor (PubMed:24359566). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001655 urogenital system development GO:0001822 kidney development GO:0001823 mesonephros development GO:0001865 NK T cell differentiation GO:0002062 chondrocyte differentiation GO:0002521 leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0003002 regionalization GO:0007159 leukocyte cell-cell adhesion GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007389 pattern specification process GO:0008356 asymmetric cell division GO:0009880 embryonic pattern specification GO:0009952 anterior/posterior pattern specification GO:0017145 stem cell division GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030217 T cell differentiation GO:0030278 regulation of ossification GO:0030326 embryonic limb morphogenesis GO:0032330 regulation of chondrocyte differentiation GO:0032332 positive regulation of chondrocyte differentiation GO:0034504 protein localization to nucleus GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035116 embryonic hindlimb morphogenesis GO:0035136 forelimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0042078 germ-line stem cell division GO:0042110 T cell activation GO:0042733 embryonic digit morphogenesis GO:0045444 fat cell differentiation GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045778 positive regulation of ossification GO:0045785 positive regulation of cell adhesion GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046634 regulation of alpha-beta T cell activation GO:0046635 positive regulation of alpha-beta T cell activation GO:0046637 regulation of alpha-beta T cell differentiation GO:0046638 positive regulation of alpha-beta T cell differentiation GO:0048133 male germ-line stem cell asymmetric division GO:0048232 male gamete generation GO:0048736 appendage development GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051136 regulation of NK T cell differentiation GO:0051138 positive regulation of NK T cell differentiation GO:0051216 cartilage development GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0060173 limb development GO:0061035 regulation of cartilage development GO:0061036 positive regulation of cartilage development GO:0061448 connective tissue development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0072001 renal system development GO:0098722 asymmetric stem cell division GO:0098728 germline stem cell asymmetric division GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis |
Molecular Function |
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001158 enhancer sequence-specific DNA binding GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0008022 protein C-terminus binding GO:0035326 enhancer binding |
Cellular Component |
GO:0016604 nuclear body GO:0016605 PML body GO:0016607 nuclear speck GO:0017053 transcriptional repressor complex |
KEGG | - |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System |
Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ZBTB16 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ZBTB16 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ZBTB16 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ZBTB16 in various data sets.
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Points in the above scatter plot represent the mutation difference of ZBTB16 in various data sets.
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Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZBTB16. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZBTB16. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZBTB16. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZBTB16. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ZBTB16 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ZBTB16 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ZBTB16 |
Name | zinc finger and BTB domain containing 16 |
Aliases | PLZF; promyelocytic leukaemia zinc finger; ZNF145; zinc finger protein 145 (Kruppel-like, expressed in promy ...... |
Chromosomal Location | 11q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ZBTB16 collected from DrugBank database. |
There is no record. |