Summary | |
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Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF11977 Zc3h12a-like Ribonuclease NYN domain |
Function |
May function as RNase and regulate the levels of target RNA species. |
Biological Process |
GO:0090305 nucleic acid phosphodiester bond hydrolysis |
Molecular Function |
GO:0004518 nuclease activity GO:0004519 endonuclease activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ZC3H12C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ZC3H12C in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ZC3H12C in various data sets.
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Points in the above scatter plot represent the mutation difference of ZC3H12C in various data sets.
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Summary | |
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Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZC3H12C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZC3H12C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZC3H12C. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZC3H12C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ZC3H12C expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ZC3H12C and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ZC3H12C |
Name | zinc finger CCCH-type containing 12C |
Aliases | KIAA1726; MCPIP3; MCP induced protein 3; MCP-induced protein 3; zinc finger CCCH domain-containing protein 1 ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ZC3H12C collected from DrugBank database. |
There is no record. |