Browse ZFAND6

Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF01754 A20-like zinc finger
PF01428 AN1-like Zinc finger
Function

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).

> Gene Ontology
 
Biological Process GO:0006625 protein targeting to peroxisome
GO:0007031 peroxisome organization
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0034612 response to tumor necrosis factor
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043574 peroxisomal transport
GO:0071356 cellular response to tumor necrosis factor
GO:0072662 protein localization to peroxisome
GO:0072663 establishment of protein localization to peroxisome
Molecular Function GO:0031593 polyubiquitin binding
GO:0032182 ubiquitin-like protein binding
GO:0043130 ubiquitin binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ZFAND6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ZFAND6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -1.89; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ZFAND6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3730.216
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6170.821
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2020.916
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0560.902
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.470.767
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7230.72
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0580.884
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0340.985
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.10.961
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3340.857
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1830.949
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0720.198
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ZFAND6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZFAND6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZFAND6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZFAND6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZFAND6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ZFAND6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ZFAND6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolZFAND6
Namezinc finger, AN1-type domain 6
Aliases ZFAND5B; AWP1; protein associated with PRK1; ZA20D3; zinc finger, A20 domain containing 3; Zinc finger A20 d ......
Chromosomal Location15q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ZFAND6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.