Summary | |
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Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA. |
Domain |
PF01352 KRAB box |
Function |
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. |
Biological Process |
GO:0006353 DNA-templated transcription, termination GO:0006369 termination of RNA polymerase II transcription GO:0006397 mRNA processing GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage GO:0008334 histone mRNA metabolic process GO:0031123 RNA 3'-end processing GO:0031124 mRNA 3'-end processing |
Molecular Function | - |
Cellular Component |
GO:0015030 Cajal body GO:0016604 nuclear body |
KEGG | - |
Reactome |
R-HSA-109688: Cleavage of Growing Transcript in the Termination Region R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-112297: Post-Elongation Processing of Intronless pre-mRNA R-HSA-76044: Post-Elongation Processing of the Transcript R-HSA-75067: Processing of Capped Intronless Pre-mRNA R-HSA-73857: RNA Polymerase II Transcription R-HSA-73856: RNA Polymerase II Transcription Termination R-HSA-77588: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-111367: SLBP independent Processing of Histone Pre-mRNAs |
Summary | |
---|---|
Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ZNF473 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ZNF473 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ZNF473 in various data sets.
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Points in the above scatter plot represent the mutation difference of ZNF473 in various data sets.
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Summary | |
---|---|
Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZNF473. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZNF473. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZNF473. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZNF473. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ZNF473 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ZNF473 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ZNF473 |
Name | zinc finger protein 473 |
Aliases | KIAA1141; DKFZP434N043; HZFP100; ZN473; zfp-100; zinc finger protein 100 homolog; zinc finger protein ZFP100 |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ZNF473 collected from DrugBank database. |
There is no record. |