Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain | - |
Function |
Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC. |
Biological Process |
GO:0031396 regulation of protein ubiquitination GO:0051438 regulation of ubiquitin-protein transferase activity GO:1903320 regulation of protein modification by small protein conjugation or removal |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0019787 ubiquitin-like protein transferase activity |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0031461 cullin-RING ubiquitin ligase complex GO:0031462 Cul2-RING ubiquitin ligase complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ZYG11A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ZYG11A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ZYG11A in various data sets.
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Points in the above scatter plot represent the mutation difference of ZYG11A in various data sets.
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Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZYG11A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZYG11A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZYG11A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZYG11A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ZYG11A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ZYG11A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ZYG11A |
Name | zyg-11 family member A, cell cycle regulator |
Aliases | zyg-11 homolog A (C. elegans); ZYG-11A early embryogenesis protein; zyg-11 homolog A; Protein zyg-11 homolog ...... |
Chromosomal Location | 1p32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ZYG11A collected from DrugBank database. |
There is no record. |